Complex: HIR histone chaperone complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- SGD
- ComplexAc
- CPX-124
- Systematic Name
- 2xHIR1:4xHIR2:2xHIR3:4xHPC2
- SGD ID
- SGD:S000217635
- Description
- Histone chaperone complex which promotes nucleosome assembly. Cooperates with the ASF1 (P32447) co-chaperone to deposit histone (H3/H4)2 tetramers on DNA for replication-independent chromatin assembly. Prevents SWI/SNF chromatin remodeling activity. Binds to and represses transcription of histone genes throughout the cell cycle, but does not repress transcription in G1/S phase.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables histone chaperone activity (BSR)
- Biological Process
-
- involved in negative regulation of chromatin organization (IDA)
- involved in nucleosome assembly (IDA)
- involved in regulation of chromatin organization (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
No shared annotations
References
List of references used specifically to curate the information on this page.
- Tseng CH, et al. (2025) Structural insights into the interaction of Hir2 and Hpc2 in the yeast Hir histone chaperone complex. Structure 33(8):1408-1416.e3 PMID: 40449483
- Kim HJ, et al. (2024) Structure of the Hir histone chaperone complex. Mol Cell 84(14):2601-2617.e12 PMID: 38925115
- Pham H, et al. (2007) Modeling the regulatory network of histone acetylation in Saccharomyces cerevisiae. Mol Syst Biol 3:153 PMID: 18091724
- Prochasson P, et al. (2005) The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Genes Dev 19(21):2534-9 PMID: 16264190
- Spector MS, et al. (1997) Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle. Mol Cell Biol 17(2):545-52 PMID: 9001207
Resources
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