Complex: RPD3S histone deacetylase complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1851
- Systematic Name
- EAF3:RCO1:RPD3:SIN3:UME1
- SGD ID
- SGD:S000218002
- Aliases
- RPD3C(S) ; Rpd3-Sin3 complex ; Rpd3/Sin3 complex ; Rpd3/Sin3 small histone deacetylase complex ; Rpd3S complex
- Description
- Histone deacetylase which functions by deacetylating chromatin, thereby limiting accessibility of the transcriptional machinery to the underlying DNA. RPD3S recognizes the SET2 methylated histones and deacetylates histones within transcribed sequences. This erases transcription elongation-associated histone acetylation and serves to repress the occurrence of spurious transcription initiation from cryptic start sites within open reading frames. May also act to promote nucleosome assembly like a histone chaperone and prevent RSC-dependent histone eviction from nucleosomes
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables histone deacetylase activity (BSR)
- enables transcription coregulator activity (BSR)
- Biological Process
-
- involved in negative regulation of transcription by RNA polymerase II (BSR)
- involved in nucleosome assembly (BSR)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Dong S, et al. (2023) Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res 33(10):790-801 PMID: 37666978
- Guan H, et al. (2023) Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S. Nature 620(7974):669-675 PMID: 37468628
- Zhang Y, et al. (2023) Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme. Cell Res 33(12):971-974 PMID: 37845487
Resources
IntAct | ModelArchive | PDB:7YI0 | PDB:7YI3 | PDB:8KC7 ... Show all Show fewer