Gene Ontology Help

Vacuolar proton translocating ATPase complex, vacuole variant Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Translocates protons across a lipid bilayer via an ATP-driven rotary mechanism, thus acidifing the lumen of its resident organelle. Membrane-bound ion transporters/proton exchangers use the resulting pH gradient to sequester metal ions to the vacuole and other cellular organelles. The combined action of the V-ATPase and membrane transporters plays a key role in maintaining cellular homoeostasis. The variant of the complex containing the VPH1 subunit results in the retention of the V-ATPase complex on vacuole membranes. When yeast cells are deprived of glucose, the V1 and VO regions separate and are no longer able to hydrolyze ATP and transport protons. Reassembly is mediated by the RAVE complex (CPX-1627).
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

transmembrane transporter activity, homeostatic process, intracellular monoatomic ion homeostasis, monoatomic ion transport, transmembrane transport, transport, membrane