Complex: ELG1-RFC complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-422
- Systematic Name
- ELG1:RFC2:RFC3:RFC4:RFC5
- SGD ID
- SGD:S000217624
- Aliases
- Elg1 replication factor C-like complex ; Elg1-RFC-like complex ; Elg1-RLC
- Description
- Role in sister chromatid cohesion, unloading both unmodified and SUMOylated PCNA from DNA following replication. This is a genome-wide process and follows Okazaki fragment ligation.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
PDB Structure
When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.
| 8THB |
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables DNA clamp unloader activity (IDA)
- enables chromatin binding (IDA)
- Biological Process
-
- involved in DNA clamp unloading (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Zheng F, et al. (2024) Structure of the PCNA unloader Elg1-RFC. Sci Adv 10(9):eadl1739 PMID: 38427736
- Kubota T, et al. (2015) Replication-Coupled PCNA Unloading by the Elg1 Complex Occurs Genome-wide and Requires Okazaki Fragment Ligation. Cell Rep 12(5):774-87 PMID: 26212319
- Kubota T, et al. (2013) The Elg1 replication factor C-like complex functions in PCNA unloading during DNA replication. Mol Cell 50(2):273-80 PMID: 23499004
- Bylund GO and Burgers PM (2005) Replication protein A-directed unloading of PCNA by the Ctf18 cohesion establishment complex. Mol Cell Biol 25(13):5445-55 PMID: 15964801
Resources
IntAct | ModelArchive | PDB:8THB ... Show all Show fewer