Gene Ontology Help

Eukaryotic translation initiation factor 4F complex, variant TIF4631 Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Binds the 5-prime cap of messenger RNAs to recruit mRNA to the ribosome during translation initiation. During cap-dependent translation, eIF4G1 (TIF4631) brings the 5' end of the mRNA in proximity with the helicase eIF4A (TIF1,TIF2) through interactions with eIF4E (CDC33). Facilitates 48S pre-initiation complex formation through interaction with eIF3 (CPX-1831) in the 43S pre-initiation complex. The relatively weak helicase activity of eIF4A is presumed to be required for unwinding mRNA secondary structures. The poly(A) binding protein PAB1 can bind to eIF4G1 act to stimulate cap-dependent translation initiation, even in the absence of a poly(A) tail.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

RNA binding, helicase activity, ion binding, translation factor activity, RNA binding, regulation of translation, organelle, ribosome, intracellular non-membrane-bounded organelle