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GAL1-GAL80 transcription regulation complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Acts to relieve the repression of the GAL4 positive regulator of gene expression. The GAL network is a small set of genes that regulates galactose import and metabolism. The transcriptional activator GAL4 activates a set of enzymatic and regulatory genes by binding to their promoter regions. When galactose is the sole carbon source, the galactose-metabolizing enzymes are expressed at 1000 times their level in glucose. In the absence of galactose, GAL4 activity is repressed by forming a complex with the transcriptional repressor GAL80 (CPX-1044). In the presence of galactose and ATP, the GAL1-GAL80 complex forms, removing GAL80 from the GAL4-activation domain, which is then able to recruit the transcriptional machinery. It is also possible a tripartite complex forms (GAL4-GAL80-GAL1), which counterbalances the effect of GAL80 on GAL4 and allows GAL4 to interact with promoters. GAL1 primarily binds with ATP and galactose in the cytoplasm, then moves into the nucleus to interact with GAL80. A paralogous complex, GAL3-GAL80 (CPX-1042) can also form and appears to have significantly higher activity as a transcriptional inducer of GAL genes. The importance of GAL1-GAL80 is unclear as it appears that GAL1 is not sufficiently expressed in the absence of galactose to serve as an inducer but other evidence suggests the complex may be required for the continued expression of the GAL genes.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

carbohydrate metabolic process, response to chemical, small molecule metabolic process, nucleus, organelle

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Cellular Component

Manually curated GO annotations reflect our best understanding of the basic cellular component for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.