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VPS4 complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
An AAA-ATPase that is probably the main energy-providing system for the membrane deformation and abscission function of the ESCRT machinery consisting of ESCRT-0 (CPX-1622), -I (CPX-940), -II (CPX-1623), -III (CPX-1624) and -IV (this complex) . Required for the dissociation and recycling of ESCRT-III complex subunits from vesicle and plasma membranes as well as the midbody during the final stages of cytokinesis where it causes constriction of the ESCRT-III polymer and fission of the associated membrane neck. Multiple disassembly reactions are performed until ESCRT-III dissociation has been completed. VPS4 ATPase activity is regulated by a) ESCRT-III interactions with VPS4 which enhance ATP hydrolysis by relieving autoinhibition of the AAA domain and b) binding of the VTA1 homodimers (Q06263) which both promotes VPS4 oligomerization and enhances ATP hydrolysis. Binding of ESCRT-III subunits DID2 (P69771) or VPS60 (Q03390) to the amino-terminal of VTA1 relieves autoinhibition within VTA1 to further enhance stimulation of VPS4 ATP hydrolysis. Binding of IST1 (P53843) to VPS4 negatively regulates VPS4 activity by blocking binding to the ESCRT machinery.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

ATP hydrolysis activity, hydrolase activity, ion binding, catabolic process, cellular component assembly, endosomal transport, membrane organization, organelle assembly, transport, vacuolar transport, vesicle organization, vesicle-mediated transport, membrane, plasma membrane

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Cellular Component

Manually curated GO annotations reflect our best understanding of the basic cellular component for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.