Primary Literature
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- Masnovo C, et al. (2024) Stabilization of expandable DNA repeats by the replication factor Mcm10 promotes cell viability. Nat Commun 15(1):10532 PMID: 39627228
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- Langston LD, et al. (2023) Mechanism of eukaryotic origin unwinding is a dual helicase DNA shearing process. Proc Natl Acad Sci U S A 120(52):e2316466120 PMID: 38109526
- Ramírez Montero D, et al. (2023) Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation. Nat Commun 14(1):2082 PMID: 37059705
- Xu Z, et al. (2023) Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun 14(1):5849 PMID: 37730685
- Dmowski M, et al. (2022) Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex. DNA Repair (Amst) 110:103272 PMID: 35038632
- Reusswig KU, et al. (2022) Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions. Nat Commun 13(1):7014 PMID: 36400763
- Yao NY, et al. (2022) CMG helicase can use ATPγS to unwind DNA: Implications for the rate-limiting step in the reaction mechanism. Proc Natl Acad Sci U S A 119(4) PMID: 35042821
- Baretić D, et al. (2020) Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork. Mol Cell 78(5):926-940.e13 PMID: 32369734
- Deegan TD, et al. (2020) CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold. Elife 9 PMID: 32804080
- Denkiewicz-Kruk M, et al. (2020) Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase-Pol ε Interaction. Int J Mol Sci 21(24) PMID: 33322195
- Devbhandari S and Remus D (2020) Rad53 limits CMG helicase uncoupling from DNA synthesis at replication forks. Nat Struct Mol Biol 27(5):461-471 PMID: 32341532
- Yuan Z, et al. (2020) Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome. Nat Commun 11(1):3156 PMID: 32572031
- Yuan Z, et al. (2020) DNA unwinding mechanism of a eukaryotic replicative CMG helicase. Nat Commun 11(1):688 PMID: 32019936
- Jedrychowska M, et al. (2019) Defects in the GINS complex increase the instability of repetitive sequences via a recombination-dependent mechanism. PLoS Genet 15(12):e1008494 PMID: 31815930
- Mukherjee PP and Labib KPM (2019) In Vitro Reconstitution Defines the Minimal Requirements for Cdc48-Dependent Disassembly of the CMG Helicase in Budding Yeast. Cell Rep 28(11):2777-2783.e4 PMID: 31509741
- Yuan Z, et al. (2019) Ctf4 organizes sister replisomes and Pol α into a replication factory. Elife 8 PMID: 31589141
- Aria V and Yeeles JTP (2018) Mechanism of Bidirectional Leading-Strand Synthesis Establishment at Eukaryotic DNA Replication Origins. Mol Cell 73(2):199-211.e10 PMID: 30451148
- Evrin C, et al. (2018) Histone H2A-H2B binding by Pol α in the eukaryotic replisome contributes to the maintenance of repressive chromatin. EMBO J 37(19) PMID: 30104407
- Ishimi Y (2018) Regulation of MCM2-7 function. Genes Genet Syst 93(4):125-133 PMID: 30369561
- Abid Ali F, et al. (2017) Cryo-EM structure of a licensed DNA replication origin. Nat Commun 8(1):2241 PMID: 29269875
- Bai L, et al. (2017) Architecture of the Saccharomyces cerevisiae Replisome. Adv Exp Med Biol 1042:207-228 PMID: 29357060
- Langston LD, et al. (2017) Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks. Elife 6 PMID: 28869037
- Lewis JS, et al. (2017) Single-molecule visualization of <i>Saccharomyces cerevisiae</i> leading-strand synthesis reveals dynamic interaction between MTC and the replisome. Proc Natl Acad Sci U S A 114(40):10630-10635 PMID: 28923950
- Maric M, et al. (2017) Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication. Cell Rep 18(13):3033-3042 PMID: 28355556
- Zhou Y, et al. (2017) Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells in <i>Arabidopsis thaliana</i>. Proc Natl Acad Sci U S A 114(18):4833-4838 PMID: 28428341
- Douglas ME and Diffley JFX (2016) Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex. J Biol Chem 291(11):5879-5888 PMID: 26719337
- O'Donnell M and Li H (2016) The Eukaryotic Replisome Goes Under the Microscope. Curr Biol 26(6):R247-56 PMID: 27003891
- Yuan Z, et al. (2016) Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat Struct Mol Biol 23(3):217-24 PMID: 26854665
- Maculins T, et al. (2015) Tethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase. Curr Biol 25(17):2254-9 PMID: 26255844
- Sun J, et al. (2015) The architecture of a eukaryotic replisome. Nat Struct Mol Biol 22(12):976-82 PMID: 26524492
- Bruck I and Kaplan DL (2014) The replication initiation protein Sld2 regulates helicase assembly. J Biol Chem 289(4):1948-59 PMID: 24307213
- Georgescu RE, et al. (2014) Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork. Nat Struct Mol Biol 21(8):664-70 PMID: 24997598
- Langston LD, et al. (2014) CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication. Proc Natl Acad Sci U S A 111(43):15390-5 PMID: 25313033
- Simon AC, et al. (2014) A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome. Nature 510(7504):293-297 PMID: 24805245