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CDC48-RAD23-UFD2 complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
A type II AAA ATPase that is involved in the dislocation/extraction step of its substrate proteins from cellular structures or multiprotein complexes into the cytosol where they are largely degraded by the proteasome.. Role in the escort pathway of proteasomal protein degradation, linking the ubiquitylation of specific substrates directly to their delivery to the proteasome. Oligo-ubiquitylated substrates are recognized and extracted by CDC48. UFD2 modifies the client proteins with lys-48-linked chains of four to six ubiquitins. RAD23 is recruited to the ternary complex, in which its UBL domain associates with UFD2, and then CDC48 remodels the complex to release the RAD23-ubiquitylated substrate complex which binds to the proteasome and delivers the substrate for degradation.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

molecular function, catabolic process, proteolysis involved in protein catabolic process, response to chemical, response to stress

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.