Gene Ontology Help

Nuclear meiotic cohesin complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Required for sister chromatid cohesion during meiotic cell division, which enables cells to attach sister kinetochores to microtubules with opposing polarity (bi-orientation) and subsequently resists the tendency of these microtubules to pull chromatids toward opposite spindle poles. Before the commencement of replication, the cohesin complex is loaded onto DNA. The arms of the SMC1/3 molecules embrace the DNA, thereby forming a ring of approx. 40 nm diameter. The head domains of SMC1 and SMC3 are locked together by REC8. Cohesion might be generated as the replication fork passes through the ring, entrapping both sister chromatids inside. At the metaphase to anaphase transition, REC8 is cleaved by separase, thereby opening the lock of the SMC1/3 head domains. The ring opens and sister chromatids can be pulled to opposite spindle poles. REC8 is required to efficiently recruit meiotic axis proteins such as RED1 and evenly distribute these along the meiotic chromosomes.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

chromatin binding, biological process, nucleus, organelle