Vacuolar SNARE complex VAM3-VTI1-VAM7-YKT6

Primary Literature

Barz S, et al. (2020) Atg1 kinase regulates autophagosome-vacuole fusion by controlling SNARE bundling. EMBO Rep 21(12):e51869 PMID: 33274589
Bas L, et al. (2018) Reconstitution reveals Ykt6 as the autophagosomal SNARE in autophagosome-vacuole fusion. J Cell Biol 217(10):3656-3669 PMID: 30097514
Gao J, et al. (2018) A novel in vitro assay reveals SNARE topology and the role of Ykt6 in autophagosome fusion with vacuoles. J Cell Biol 217(10):3670-3682 PMID: 30097515
Hong W and Lev S (2014) Tethering the assembly of SNARE complexes. Trends Cell Biol 24(1):35-43 PMID: 24119662
Wickner W (2010) Membrane fusion: five lipids, four SNAREs, three chaperones, two nucleotides, and a Rab, all dancing in a ring on yeast vacuoles. Annu Rev Cell Dev Biol 26:115-36 PMID: 20521906
Mima J and Wickner W (2009) Phosphoinositides and SNARE chaperones synergistically assemble and remodel SNARE complexes for membrane fusion. Proc Natl Acad Sci U S A 106(38):16191-6 PMID: 19805279
Fratti RA, et al. (2007) Stringent 3Q.1R composition of the SNARE 0-layer can be bypassed for fusion by compensatory SNARE mutation or by lipid bilayer modification. J Biol Chem 282(20):14861-7 PMID: 17400548
Jahn R and Scheller RH (2006) SNAREs--engines for membrane fusion. Nat Rev Mol Cell Biol 7(9):631-43 PMID: 16912714
Kweon Y, et al. (2003) Ykt6p is a multifunctional yeast R-SNARE that is required for multiple membrane transport pathways to the vacuole. Mol Biol Cell 14(5):1868-81 PMID: 12802061
Parlati F, et al. (2002) Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity. Proc Natl Acad Sci U S A 99(8):5424-9 PMID: 11959998
Fukuda R, et al. (2000) Functional architecture of an intracellular membrane t-SNARE. Nature 407(6801):198-202 PMID: 11001059
Tsui MM and Banfield DK (2000) Yeast Golgi SNARE interactions are promiscuous. J Cell Sci 113 ( Pt 1):145-52 PMID: 10591633

Additional Literature

Klössel S, et al. (2024) Yeast TLDc domain proteins regulate assembly state and subcellular localization of the V-ATPase. EMBO J 43(9):1870-1897 PMID: 38589611

Song H and Wickner WT (2021) Fusion of tethered membranes can be driven by Sec18/NSF and Sec17/αSNAP without HOPS. Elife 10 PMID: 34698639

Harner M and Wickner W (2018) Assembly of intermediates for rapid membrane fusion. J Biol Chem 293(4):1346-1352 PMID: 29208657

Orr A, et al. (2017) HOPS catalyzes the interdependent assembly of each vacuolar SNARE into a SNARE complex. Mol Biol Cell 28(7):975-983 PMID: 28148647

Liu X, et al. (2016) The Atg17-Atg31-Atg29 Complex Coordinates with Atg11 to Recruit the Vam7 SNARE and Mediate Autophagosome-Vacuole Fusion. Curr Biol 26(2):150-160 PMID: 26774783

Miner GE, et al. (2016) The Central Polybasic Region of the Soluble SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Vam7 Affects Binding to Phosphatidylinositol 3-Phosphate by the PX (Phox Homology) Domain. J Biol Chem 291(34):17651-63 PMID: 27365394

Furukawa N and Mima J (2014) Multiple and distinct strategies of yeast SNAREs to confer the specificity of membrane fusion. Sci Rep 4:4277 PMID: 24589832

Karunakaran S and Fratti RA (2013) The lipid composition and physical properties of the yeast vacuole affect the hemifusion-fusion transition. Traffic 14(6):650-62 PMID: 23438067

Karunakaran V and Wickner W (2013) Fusion proteins and select lipids cooperate as membrane receptors for the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) Vam7p. J Biol Chem 288(40):28557-66 PMID: 23955338

Izawa R, et al. (2012) Distinct contributions of vacuolar Qabc- and R-SNARE proteins to membrane fusion specificity. J Biol Chem 287(5):3445-53 PMID: 22174414

Fratti RA and Wickner W (2007) Distinct targeting and fusion functions of the PX and SNARE domains of yeast vacuolar Vam7p. J Biol Chem 282(17):13133-8 PMID: 17347148

Hofmann MW, et al. (2006) Self-interaction of a SNARE transmembrane domain promotes the hemifusion-to-fusion transition. J Mol Biol 364(5):1048-60 PMID: 17054985

Paumet F, et al. (2001) A t-SNARE of the endocytic pathway must be activated for fusion. J Cell Biol 155(6):961-8 PMID: 11739407

Tsui MM, et al. (2001) Selective formation of Sed5p-containing SNARE complexes is mediated by combinatorial binding interactions. Mol Biol Cell 12(3):521-38 PMID: 11251068

McNew JA, et al. (2000) Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Nature 407(6801):153-9 PMID: 11001046

Coe JG, et al. (1999) A role for Tlg1p in the transport of proteins within the Golgi apparatus of Saccharomyces cerevisiae. Mol Biol Cell 10(7):2407-23 PMID: 10397773

Sato K and Wickner W (1998) Functional reconstitution of ypt7p GTPase and a purified vacuole SNARE complex. Science 281(5377):700-2 PMID: 9685264

Ungermann C, et al. (1998) A vacuolar v-t-SNARE complex, the predominant form in vivo and on isolated vacuoles, is disassembled and activated for docking and fusion. J Cell Biol 140(1):61-9 PMID: 9425154

Darsow T, et al. (1997) A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole. J Cell Biol 138(3):517-29 PMID: 9245783

Weimbs T, et al. (1997) A conserved domain is present in different families of vesicular fusion proteins: a new superfamily. Proc Natl Acad Sci U S A 94(7):3046-51 PMID: 9096343

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Vacuolar SNARE complex VAM3-VTI1-VAM7-YKT6 Literature

Primary Literature

Additional Literature