Gene Ontology Help

mRNA cleavage factor complex CFIA Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Required for the posttranscriptional maturation of mRNA 3' ends. CFI binds signal sequences at the 3' end of yeast mRNA. and is required for correct positioning of a larger protein complex, CPF (CPX-1053), which contains the catalytic subunits executing mRNA cleavage and polyadenylation. CFI (CPX-1896) and CFII recognize the processing signals of the RNA and perform the endonucleolytic cleavage, whereas CFI, polyadenylation factor I (PFI), and the single-polypeptide PAP1 are required for the polyadenylation step. CFIA forms a stable sub-complex
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

RNA binding, mRNA binding, mRNA processing