Gene Ontology Help

FACT complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
A heterodimeric H2A-H2B histone chaperone, that helps reorganize nucleosomes in an ATP independent fashion. It promotes histone removal, deposition and replacement on chromatin. Due to its role in chromatin dynamics, it has a role in many cellular processes related to chromatin: DNA replication, DNA damage and repair, transcription initiation and elongation. The redundant NHP6A/B proteins(P11632/P11633) are involved in FACT function and supply the DNA binding activity, potentially destabilizing nucleosomes to promote formation of alternative chromatin structures in addition to recruiting FACT.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA metabolic process, DNA replication, chromatin organization