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Signal recognition particle Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
A conserved ribonucleoprotein particle, which includes in its structure a small cytoplasmic RNA (scRNA). In co-translational targeting of membrane and secretory proteins, SRP recognizes signal sequences as soon as they emerge from the ribosomal polypeptide exit tunnel and binds to the ribosome-nascent chain complex (RNC), leading to retardation of peptide elongation. The SRP-RNC complex is targeted to the endoplasmic reticulum (ER) membrane by interaction with the SRP receptor (SR). After docking to the membrane, the RNC is transferred to the protein-conducting channel, the translocon, and protein synthesis continues. The SRP-SR complex dissociates from the ribosome and, as a result of GTP hydrolysis, SRP and SR dissociate from each other. The genes encoding scR1 and SRP54 are not essential for growth, although SRP-deficient cells grow poorly, suggesting that an alternative, SRP-independent targeting pathway(s) to the ER membrane exists.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

GTPase activity, hydrolase activity, cellular component assembly, protein-containing complex assembly

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.