Gene Ontology Help

Nuclear pore complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

The nuclear pore complex (NPC) is a large assembly embedded in the nuclear envelope of eukaryotic cells. The yeast nucleus contains approximately 200 NPCs per cell and as the sole site of macromolecular traffic between the nucleus and cytoplasm, the complex provides an important control point for the regulation of gene expression. Inert polymers and small proteins less than 9 nm in diameter or less than 30-40 kDa in mass can freely diffuse through the NPC, larger particles traverse the NPC by a facilitated mechanism with the structure able to expand radially to accommodate the passage of larger particles. The nuclear basket subunits play an active role in transcription, transcriptional memory and chromatin organization by recruiting members of the transcription machinery to the nuclear side of the NCP.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

nuclear transport, nucleocytoplasmic transport, transport, nuclear envelope