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RNA polymerase I upstream activating factor complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Binds tightly to the upstream element of the yeast Pol I promoter and is essential for a high level of transcription of the 35S rRNA gene. UAF has dual functions: both as a positive transcription factor for Pol I, and as a silencer for Pol II transcription of rRNA genes. Deletion of any one of the subunit protein genes encoding essential nonhistone proteins causes derepression of Pol II transcription of the 35S rRNA genes. The association of H3 and H4 with the other UAF components is important for the stability of UAF in vivo and, hence, for rRNA transcription by Pol I. Initiation of transcription requires the assembly of UAF, the core factor (CPX-1836), the TATA binding protein SPT15 (P13393), and RNAP-I (CPX-1664) with RRN3 (P36070) on the upstream element and core promoter. Upon transcription initiation, UAF, RRN3 and CF dissociate from the promoter.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA binding, DNA-templated transcription, biosynthetic process, transcription by RNA polymerase I, nucleus, organelle

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Cellular Component

Manually curated GO annotations reflect our best understanding of the basic cellular component for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.