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Complex: PCNA homotrimer

Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Curated by
IntAct
ComplexAc
CPX-544
Systematic Name
POL30 trimer
SGD ID
SGD:S000218021
Aliases
PCNA complex ; Proliferating Cell Nuclear Antigen ; Proliferating Cell Nuclear Antigen complex
Description
Role in DNA replication, repair, cell-cycle control, and chromatin remodeling. Exists as a double back-to-back homotrimeric ring which encircles double-stranded DNA and slides spontaneously across it. Loaded onto at template-primer junctions synthesized on unwound DNA during S phase in an ATP-dependent process by replication factor C (CPX-545), where it recruits replicative DNA polymerases and stimulates their activity. The process of chromatin assembly is tightly coupled to DNA replication or repair and the double homotrimer allows DNA polymerase delta to binds to one homotrimer whilst the chromatin assembly factor-1 CNOT7 binds to the other.

Complex Diagram

This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.

PDB Structure

When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.

1PLQ 1PLQ 1PLR 1PLR 3F1W 3F1W 3GPM 3GPM 4YHR 4YHR 5T9D 5T9D 5V7K 5V7K 5V7L 5V7L 5V7M 5V7M 6CX2 6CX2 6CX3 6CX3 6CX4 6CX4 6D0Q 6D0Q 6D0R 6D0R 6W9W 6W9W 6WAC 6WAC

Subunits

This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.

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Subunit Description Stoichiometry

Gene Ontology

Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.

Shared Annotations

This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.

References

List of references used specifically to curate the information on this page.

Resources

IntAct | ModelArchive | PDB:1PLQ | PDB:1PLR | PDB:3F1W | PDB:3GPM | PDB:4YHR | PDB:5T9D | PDB:5V7K | PDB:5V7L | PDB:5V7M ... Show all