Gene Ontology Help

NDC80 complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Crucial for the stable kinetochore-microtubule attachments that are needed to sustain the centromere tensions involved in achieving proper chromosome alignment in eukaryotic cells, with a role in chromosome alignment and microtubule-dependent control of MAD1/MAD2 and dynein complexes at kinetochores. Loss-of-function mutation of any of 4 subunits in yeast causes disrupted kinetochore-microtubule binding and inactivation of the spindle checkpoint, leading to high rate of chromosome loss.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

chromosome segregation