Gene Ontology Help

Replication fork protection complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Required for chromosome segregation during meiosis and DNA damage repair. Acts at the intra-S-phase checkpoint pathway to stabilize stalled replication forks by maintaining the replisome at the arrested sites. Coordinates leading and lagging strand synthesis and moves with the replication fork, transfering cohesin from the front of the fork to the newly synthesized DNA. Stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors and protects stalled replication forks against the fork-releasing activity of RRM3 helicase. The complex recruits the checkpoint mediator MRC1 (P25588) to the replisome to perform its checkpoint function.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA damage response, DNA metabolic process, DNA repair, regulation of DNA metabolic process, response to stress, nucleus, organelle, nuclear replication fork