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Carboxy-terminal domain protein kinase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Cyclin-dependent protein that phosphorylates RNA polymerase II (RNAPII, CPX-2662) on the carboxyl-terminal repeat domain (CTD) of its largest subunit RPB1 (P04050), which is important for efficient transcription elongation, mRNA 3′-end processing, and transcription termination of small noncoding RNAs. Also plays a role in RNA polymerase I (RNAPI, CPX-1664) transcription. Increases the correct decoding of mRNA during translation elongation by phosphorylating residue Ser-238 of RPS2 (P25443), a protein of the small ribosomal subunit (CPX-1599). Directs the association of SET2 (P46995) to RNAP II, which results in the establishment of H3K36 methylation and deacetylated chromatin in the bodies of genes. Also regulates SET1-mediated H3K4 methylation which marks the 5′ end of transcribed genes, promoting association of chromatin-remodeling and histone-modifying enzymes.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

kinase activity, transferase activity, mRNA processing, protein phosphorylation

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.