Gene Ontology Help

PAF1 complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

A multifunctional complex involved in many aspects of RNA polymerase II (Pol II) transcriptional regulation, including transcriptional elongation, 3'-terminal end processing, and histone modification. Role in 3'-end formation of mRNAs, required for the recruitment of cleavage and polyadenylation factors CFT1 and PCF11 to RNA polymerase II. Required for activation of the RAD6/UBC2-BRE1 ubiquitin ligase complex, which ubiquitinates histone H2B to form H2BK123ub1. Also required for the methylation of histone H3 by the COMPASS complex (CPX-1039) to form H3K4me, by SET2 to form H3K36me, and by DOT1 to form H3K79me.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

enzyme binding, DNA-templated transcription elongation, biosynthetic process, histone modification, protein alkylation