Gene Ontology Help

Mitochondrial 2-oxoglutarate dehydrogenase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA, NADH and CO2. Succinyl-CoA is then converted to succinate by succinyl-CoA synthetase or used as a substrate in heme biosynthesis. Acts as a major site of reactive oxygen species generation.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

oxidoreductase activity, small molecule metabolic process, mitochondrion, organelle, intracellular non-membrane-bounded organelle