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Complex: NRD1 snoRNA termination complex

Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Curated by
IntAct
ComplexAc
CPX-1316
Systematic Name
NAB3:NRD1:SEN1
SGD ID
SGD:S000218184
Aliases
NNS complex ; Nab3-Nrd1-Sen1 complex
Description
ATP-dependent 5-prime->3-prime DNA/RNA helicase complex required for transcription termination at genes encoding snRNAs and snoRNAs30 and at cryptic unstable transcripts, which are an important class of transcription units that code for ncRNA. May also include some mRNAs as substrates. NRD1 and NAB3 recognize and bind to specific motifs on the nascent RNA (GUAA/G and UCUUG respectively) NRD1 additionally interacts with phosphoryated Ser-5 of the C-terminal domain of the largest subunit of RNAPII (CPX-2662). This positions SEN1 onto the nascent RNA in close proximity to RNAPII and the complex translocates along the RNA causing dismantling of the elongation complex (ternary complexes composed of the transcribing RNA polymerase, the DNA template and the nascent RNA) in a reaction that requires the action of the helicase domain of SEN1.

Complex Diagram

This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.

PDB Structure

When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.

35022249 35022249 6GC3 6GC3 6O3W 6O3W 6O3X 6O3X 6O3Y 6O3Y 7PRD 7PRD

Subunits

This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.

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Subunit Description Stoichiometry

Gene Ontology

Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.

Shared Annotations

This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.

References

List of references used specifically to curate the information on this page.

External Identifiers

IntEnz: 3.6.4

Resources

IntAct | ModelArchive | PDB:35022249 | PDB:6GC3 | PDB:6O3W | PDB:6O3X | PDB:6O3Y | PDB:7PRD