Primary Literature
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- Butryn A, et al. (2025) Unidirectional MCM translocation away from ORC drives origin licensing. Nat Commun 16(1):782 PMID: 39824870
- Faull SV, et al. (2025) MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis. Nat Commun 16(1): 14. PMID: 39747125
- Reuter LM, et al. (2024) MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing. Nat Commun 15(1):7306 PMID: 39181881
- Chacin E, et al. (2023) Establishment and function of chromatin organization at replication origins. Nature 616(7958):836-842 PMID: 37020028
- Sánchez H, et al. (2023) A chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint. Nat Commun 14(1):6735 PMID: 37872142
- Tye BK and Zhai Y (2023) The Origin Recognition Complex: From Origin Selection to Replication Licensing in Yeast and Humans. Biology (Basel) 13(1) PMID: 38248444
- Zhang A, et al. (2023) Changing protein-DNA interactions promote ORC binding-site exchange during replication origin licensing. Proc Natl Acad Sci U S A 120(30):e2305556120 PMID: 37463200
- Li S, et al. (2022) Origin recognition complex harbors an intrinsic nucleosome remodeling activity. Proc Natl Acad Sci U S A 119(42):e2211568119 PMID: 36215487
- Regan-Mochrie G, et al. (2022) Yeast ORC sumoylation status fine-tunes origin licensing. Genes Dev 36(13-14):807-21 PMID: 35926881
- Dukaj L and Rhind N (2021) The capacity of origins to load MCM establishes replication timing patterns. PLoS Genet 17(3):e1009467 PMID: 33764973
- Gupta S, et al. (2021) A helicase-tethered ORC flip enables bidirectional helicase loading. Elife 10 PMID: 34882090
- Sánchez H, et al. (2021) DNA replication origins retain mobile licensing proteins. Nat Commun 12(1):1908 PMID: 33772005
- Amin A, et al. (2020) An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication. Cell Rep 30(10):3323-3338.e6 PMID: 32160540
- Schmidt JM and Bleichert F (2020) Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun 11(1):4263 PMID: 32848132
- Topal S, et al. (2020) INO80C Remodeler Maintains Genomic Stability by Preventing Promiscuous Transcription at Replication Origins. Cell Rep 32(10):108106 PMID: 32905765
- Villar-Fernández MA, et al. (2020) Biochemical and functional characterization of a meiosis-specific Pch2/ORC AAA+ assembly. Life Sci Alliance 3(11) PMID: 32826290
- Yuan Z, et al. (2020) Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc Natl Acad Sci U S A 117(30):17747-17756 PMID: 32669428
- Kawakami H, et al. (2019) Specific basic patch-dependent multimerization of Saccharomyces cerevisiae ORC on single-stranded DNA promotes ATP hydrolysis. Genes Cells 24(9):608-618 PMID: 31233675
- Miller TCR, et al. (2019) Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM. Nature 575(7784):704-710 PMID: 31748745
- Li N, et al. (2018) Structure of the origin recognition complex bound to DNA replication origin. Nature 559(7713):217-222 PMID: 29973722
- Singh VK, et al. (2018) Prediction of replication sites in Saccharomyces cerevisiae genome using DNA segment properties: Multi-view ensemble learning (MEL) approach. Biosystems 163:59-69 PMID: 29233729
- Xue H, et al. (2018) Visualizing the Interaction Between the Qdot-labeled Protein and Site-specifically Modified λ DNA at the Single Molecule Level. J Vis Exp PMID: 30080193
- Coster G and Diffley JFX (2017) Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading. Science 357(6348):314-318 PMID: 28729513
- Xue H, et al. (2017) Utilizing Biotinylated Proteins Expressed in Yeast to Visualize DNA-Protein Interactions at the Single-Molecule Level. Front Microbiol 8:2062 PMID: 29123507
- Yuan Z, et al. (2017) Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. Nat Struct Mol Biol 24(3):316-324 PMID: 28191893
- Hyrien O (2016) How MCM loading and spreading specify eukaryotic DNA replication initiation sites. F1000Res 5 PMID: 27635237
- Kawakami H, et al. (2016) Rapid Purification and Characterization of Mutant Origin Recognition Complexes in Saccharomyces cerevisiae. Front Microbiol 7:521 PMID: 27148210
- Syed S, et al. (2016) A Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression. PLoS Genet 12(12):e1006451 PMID: 27923055
- Belsky JA, et al. (2015) Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly. Genes Dev 29(2):212-24 PMID: 25593310
- Duzdevich D, et al. (2015) The dynamics of eukaryotic replication initiation: origin specificity, licensing, and firing at the single-molecule level. Mol Cell 58(3):483-94 PMID: 25921072
- Kawakami H, et al. (2015) Specific binding of eukaryotic ORC to DNA replication origins depends on highly conserved basic residues. Sci Rep 5:14929 PMID: 26456755
- Kliszczak M, et al. (2015) Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells. Oncotarget 6(38):40464-79 PMID: 26588054
- Yeeles JT, et al. (2015) Regulated eukaryotic DNA replication origin firing with purified proteins. Nature 519(7544):431-5 PMID: 25739503
- Bogenschutz NL, et al. (2014) Initiation of DNA replication from non-canonical sites on an origin-depleted chromosome. PLoS One 9(12):e114545 PMID: 25486280
- On KF, et al. (2014) Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication. EMBO J 33(6):605-20 PMID: 24566989
- Bleichert F, et al. (2013) A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation. Elife 2:e00882 PMID: 24137536
- Evrin C, et al. (2013) In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization. Nucleic Acids Res 41(5):3162-72 PMID: 23376927
- Frigola J, et al. (2013) ATPase-dependent quality control of DNA replication origin licensing. Nature 495(7441):339-43 PMID: 23474987
- Hizume K, et al. (2013) Concerted interaction between origin recognition complex (ORC), nucleosomes and replication origin DNA ensures stable ORC-origin binding. Genes Cells 18(9):764-79 PMID: 23795651
- Hoggard T, et al. (2013) A Link between ORC-origin binding mechanisms and origin activation time revealed in budding yeast. PLoS Genet 9(9):e1003798 PMID: 24068963
- Mayan MD (2013) RNAP-II molecules participate in the anchoring of the ORC to rDNA replication origins. PLoS One 8(1):e53405 PMID: 23308214
- Gidvani RD, et al. (2012) A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations. BMC Syst Biol 6:78 PMID: 22738223
- Li H and Stillman B (2012) The origin recognition complex: a biochemical and structural view. Subcell Biochem 62:37-58 PMID: 22918579
- Mehanna A and Diffley JF (2012) Pre-replicative complex assembly with purified proteins. Methods 57(2):222-6 PMID: 22732456
- Sun J, et al. (2012) Cdc6-induced conformational changes in ORC bound to origin DNA revealed by cryo-electron microscopy. Structure 20(3):534-44 PMID: 22405012
- Zhang X, et al. (2012) Functions of protosilencers in the formation and maintenance of heterochromatin in Saccharomyces cerevisiae. PLoS One 7(5):e37092 PMID: 22615905
- Bryant JA and Aves SJ (2011) Initiation of DNA replication: functional and evolutionary aspects. Ann Bot 107(7):1119-26 PMID: 21508040
- Chang F, et al. (2011) High-resolution analysis of four efficient yeast replication origins reveals new insights into the ORC and putative MCM binding elements. Nucleic Acids Res 39(15):6523-35 PMID: 21558171
- Chen S and Bell SP (2011) CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6. Genes Dev 25(4):363-72 PMID: 21289063
- Ehrentraut S, et al. (2011) Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79. Genes Dev 25(17):1835-46 PMID: 21896656
- Guernsey DL, et al. (2011) Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome. Nat Genet 43(4):360-4 PMID: 21358631
- Takara TJ and Bell SP (2011) Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases. EMBO J 30(24):4885-96 PMID: 22045335
- Vader G, et al. (2011) Protection of repetitive DNA borders from self-induced meiotic instability. Nature 477(7362):115-9 PMID: 21822291
- Zheng Z and Wang Y (2011) DNA binding proteins: outline of functional classification. Biomol Concepts 2(4):293-303 PMID: 25962037
- Álamo MM, et al. (2010) Structural analysis of the interactions between hsp70 chaperones and the yeast DNA replication protein Orc4p. J Mol Biol 403(1):24-39 PMID: 20732327
- Berbenetz NM, et al. (2010) Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure. PLoS Genet 6(9):e1001092 PMID: 20824081
- Chowdhury A, et al. (2010) The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation. Mol Cell Biol 30(6):1495-507 PMID: 20065034
- Eaton ML, et al. (2010) Conserved nucleosome positioning defines replication origins. Genes Dev 24(8):748-53 PMID: 20351051
- Hickman MA and Rusche LN (2010) Transcriptional silencing functions of the yeast protein Orc1/Sir3 subfunctionalized after gene duplication. Proc Natl Acad Sci U S A 107(45):19384-9 PMID: 20974972
- Jones DR, et al. (2010) The Dbf4 motif C zinc finger promotes DNA replication and mediates resistance to genotoxic stress. Cell Cycle 9(10):2018-26 PMID: 20436286
- Kawakami H and Katayama T (2010) DnaA, ORC, and Cdc6: similarity beyond the domains of life and diversity. Biochem Cell Biol 88(1):49-62 PMID: 20130679
- Lõoke M, et al. (2010) Relicensing of transcriptionally inactivated replication origins in budding yeast. J Biol Chem 285(51):40004-11 PMID: 20962350
- Lydeard JR, et al. (2010) Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly. Genes Dev 24(11):1133-44 PMID: 20516198
- Müller P, et al. (2010) The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin. Genes Dev 24(13):1418-33 PMID: 20595233
- Ozaydin B and Rine J (2010) Expanded roles of the origin recognition complex in the architecture and function of silenced chromatin in Saccharomyces cerevisiae. Mol Cell Biol 30(3):626-39 PMID: 19948882
- Preston MA and Phizicky EM (2010) The requirement for the highly conserved G-1 residue of Saccharomyces cerevisiae tRNAHis can be circumvented by overexpression of tRNAHis and its synthetase. RNA 16(5):1068-77 PMID: 20360392
- Tsakraklides V and Bell SP (2010) Dynamics of pre-replicative complex assembly. J Biol Chem 285(13):9437-9443 PMID: 20097898
- Weber JM and Ehrenhofer-Murray AE (2010) Design of a minimal silencer for the silent mating-type locus HML of Saccharomyces cerevisiae. Nucleic Acids Res 38(22):7991-8000 PMID: 20699276
- Das-Bradoo S and Bielinsky AK (2009) Replication initiation point mapping: approach and implications. Methods Mol Biol 521:105-20 PMID: 19563103
- Evrin C, et al. (2009) A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication. Proc Natl Acad Sci U S A 106(48):20240-5 PMID: 19910535
- Godoy PD, et al. (2009) Trypanosome prereplication machinery contains a single functional orc1/cdc6 protein, which is typical of archaea. Eukaryot Cell 8(10):1592-603 PMID: 19717742
- Hou Z, et al. (2009) Phylogenetic conservation and homology modeling help reveal a novel domain within the budding yeast heterochromatin protein Sir1. Mol Cell Biol 29(3):687-702 PMID: 19029247
- Makise M, et al. (2009) Linkage between phosphorylation of the origin recognition complex and its ATP binding activity in Saccharomyces cerevisiae. J Biol Chem 284(6):3396-407 PMID: 19068484
- Rehman MA and Yankulov K (2009) The dual role of autonomously replicating sequences as origins of replication and as silencers. Curr Genet 55(4):357-63 PMID: 19633981
- Remus D, et al. (2009) Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell 139(4):719-30 PMID: 19896182
- Shor E, et al. (2009) The origin recognition complex interacts with a subset of metabolic genes tightly linked to origins of replication. PLoS Genet 5(12):e1000755 PMID: 19997491
- Cao XQ, et al. (2008) Structural properties of replication origins in yeast DNA sequences. Phys Biol 5(3):036012 PMID: 18824790
- Casey L, et al. (2008) Conversion of a replication origin to a silencer through a pathway shared by a Forkhead transcription factor and an S phase cyclin. Mol Biol Cell 19(2):608-22 PMID: 18045995
- Chang F, et al. (2008) Analysis of chromosome III replicators reveals an unusual structure for the ARS318 silencer origin and a conserved WTW sequence within the origin recognition complex binding site. Mol Cell Biol 28(16):5071-81 PMID: 18573888
- Chen Z, et al. (2008) The architecture of the DNA replication origin recognition complex in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 105(30):10326-31 PMID: 18647841
- Crampton A, et al. (2008) An ARS element inhibits DNA replication through a SIR2-dependent mechanism. Mol Cell 30(2):156-66 PMID: 18439895
- Fox CA and Weinreich M (2008) Beyond heterochromatin: SIR2 inhibits the initiation of DNA replication. Cell Cycle 7(21):3330-4 PMID: 18948737
- Gupta A, et al. (2008) Plasmodium falciparum origin recognition complex subunit 5: functional characterization and role in DNA replication foci formation. Mol Microbiol 69(3):646-65 PMID: 18554328
- Kan J, et al. (2008) Origin recognition complex (ORC) mediates histone 3 lysine 4 methylation through cooperation with Spp1 in Saccharomyces cerevisiae. J Biol Chem 283(49):33803-7 PMID: 18845545
- Kato H, et al. (2008) Schizosaccharomyces pombe Orc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle. Cell Cycle 7(8):1085-96 PMID: 18414064
- Makise M, et al. (2008) Analysis of origin recognition complex in saccharomyces cerevisiae by use of Degron mutants. J Biochem 143(4):455-65 PMID: 18211918
- Marcand S, et al. (2008) Multiple pathways inhibit NHEJ at telomeres. Genes Dev 22(9):1153-8 PMID: 18451106
- Safi A, et al. (2008) Evolution of new function through a single amino acid change in the yeast repressor Sum1p. Mol Cell Biol 28(8):2567-78 PMID: 18268008
- Takehara M, et al. (2008) Analysis of mutant origin recognition complex with reduced ATPase activity in vivo and in vitro. Biochem J 413(3):535-43 PMID: 18393942
- Zou Y and Bi X (2008) Positive roles of SAS2 in DNA replication and transcriptional silencing in yeast. Nucleic Acids Res 36(16):5189-200 PMID: 18682530
- Chen S, et al. (2007) Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading. Genes Dev 21(22):2897-907 PMID: 18006685
- Chesnokov IN (2007) Multiple functions of the origin recognition complex. Int Rev Cytol 256:69-109 PMID: 17241905
- Da-Silva LF and Duncker BP (2007) ORC function in late G1: maintaining the license for DNA replication. Cell Cycle 6(2):128-30 PMID: 17314509
- Kehayova PD and Liu DR (2007) In vivo evolution of an RNA-based transcriptional silencing domain in S. cerevisiae. Chem Biol 14(1):65-74 PMID: 17254953
- Makise M, et al. (2007) Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells. Biochem J 402(2):397-403 PMID: 17107343
- Mori S and Shirahige K (2007) Perturbation of the activity of replication origin by meiosis-specific transcription. J Biol Chem 282(7):4447-4452 PMID: 17170106
- Shimada K and Gasser SM (2007) The origin recognition complex functions in sister-chromatid cohesion in Saccharomyces cerevisiae. Cell 128(1):85-99 PMID: 17218257
- Siddiqui K and Stillman B (2007) ATP-dependent assembly of the human origin recognition complex. J Biol Chem 282(44):32370-83 PMID: 17716973
- Speck C and Stillman B (2007) Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication. J Biol Chem 282(16):11705-14 PMID: 17314092
- Suter B, et al. (2007) Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p. BMC Biol 5:38 PMID: 17880717
- Bolon YT and Bielinsky AK (2006) The spatial arrangement of ORC binding modules determines the functionality of replication origins in budding yeast. Nucleic Acids Res 34(18):5069-80 PMID: 16984967
- Gabrielse C, et al. (2006) A Dbf4p BRCA1 C-terminal-like domain required for the response to replication fork arrest in budding yeast. Genetics 173(2):541-55 PMID: 16547092
- Gibson DG, et al. (2006) Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae. Genes Cells 11(6):557-73 PMID: 16716188
- Hou Z, et al. (2006) Structure of the Sir3 protein bromo adjacent homology (BAH) domain from S. cerevisiae at 1.95 A resolution. Protein Sci 15(5):1182-6 PMID: 16641491
- Kawasaki Y, et al. (2006) Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro. Genes Cells 11(7):745-56 PMID: 16824194
- McConnell KH, et al. (2006) Tolerance of Sir1p/origin recognition complex-dependent silencing for enhanced origin firing at HMRa. Mol Cell Biol 26(5):1955-66 PMID: 16479013
- Ramachandran L, et al. (2006) Evidence for ORC-dependent repression of budding yeast genes induced by starvation and other stresses. FEMS Yeast Res 6(5):763-76 PMID: 16879427
- Randell JC, et al. (2006) Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase. Mol Cell 21(1):29-39 PMID: 16387651
- Semple JW, et al. (2006) An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes. EMBO J 25(21):5150-8 PMID: 17053779
- Zou Y, et al. (2006) Asymmetric positioning of nucleosomes and directional establishment of transcriptionally silent chromatin by Saccharomyces cerevisiae silencers. Mol Cell Biol 26(20):7806-19 PMID: 16908533
- Archambault V, et al. (2005) Disruption of mechanisms that prevent rereplication triggers a DNA damage response. Mol Cell Biol 25(15):6707-21 PMID: 16024805
- Biswas SB, et al. (2005) Control of ATP-dependent binding of Saccharomyces cerevisiae origin recognition complex to autonomously replicating DNA sequences. Cell Cycle 4(3):494-500 PMID: 15711121
- Cvetic C and Walter JC (2005) Eukaryotic origins of DNA replication: could you please be more specific? Semin Cell Dev Biol 16(3):343-53 PMID: 15840443
- DePamphilis ML (2005) Cell cycle dependent regulation of the origin recognition complex. Cell Cycle 4(1):70-9 PMID: 15611627
- Hou Z, et al. (2005) Structural basis of the Sir1-origin recognition complex interaction in transcriptional silencing. Proc Natl Acad Sci U S A 102(24):8489-94 PMID: 15932939
- Hsu HC, et al. (2005) Structural basis for origin recognition complex 1 protein-silence information regulator 1 protein interaction in epigenetic silencing. Proc Natl Acad Sci U S A 102(24):8519-24 PMID: 15937111
- Irlbacher H, et al. (2005) Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression. Genes Dev 19(15):1811-22 PMID: 16077008
- Lynch PJ, et al. (2005) Sum1p, the origin recognition complex, and the spreading of a promoter-specific repressor in Saccharomyces cerevisiae. Mol Cell Biol 25(14):5920-32 PMID: 15988008
- Mitkova AV, et al. (2005) Modulation of DNA synthesis in Saccharomyces cerevisiae nuclear extract by DNA polymerases and the origin recognition complex. J Biol Chem 280(8):6285-92 PMID: 15590683
- Mori Y, et al. (2005) Characterization of the origin recognition complex (ORC) from a higher plant, rice (Oryza sativa L.). Gene 353(1):23-30 PMID: 15939553
- Rice TS, et al. (2005) The highly conserved tRNAHis guanylyltransferase Thg1p interacts with the origin recognition complex and is required for the G2/M phase transition in the yeast Saccharomyces cerevisiae. Eukaryot Cell 4(4):832-5 PMID: 15821142
- Speck C, et al. (2005) ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA. Nat Struct Mol Biol 12(11):965-71 PMID: 16228006
- Trabold PA, et al. (2005) Activation of budding yeast replication origins and suppression of lethal DNA damage effects on origin function by ectopic expression of the co-chaperone protein Mge1. J Biol Chem 280(13):12413-21 PMID: 15647270
- Varrin AE, et al. (2005) A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents. Mol Cell Biol 25(17):7494-504 PMID: 16107698
- Bose ME, et al. (2004) The origin recognition complex and Sir4 protein recruit Sir1p to yeast silent chromatin through independent interactions requiring a common Sir1p domain. Mol Cell Biol 24(2):774-86 PMID: 14701749
- Bowers JL, et al. (2004) ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication. Mol Cell 16(6):967-78 PMID: 15610739
- Breier AM, et al. (2004) Prediction of Saccharomyces cerevisiae replication origins. Genome Biol 5(4):R22 PMID: 15059255
- Chastain PD, et al. (2004) Mapping subunit location on the Saccharomyces cerevisiae origin recognition complex free and bound to DNA using a novel nanoscale biopointer. J Biol Chem 279(35):36354-62 PMID: 15201282
- Geissenhöner A, et al. (2004) Dependence of ORC silencing function on NatA-mediated Nalpha acetylation in Saccharomyces cerevisiae. Mol Cell Biol 24(23):10300-12 PMID: 15542839
- Prasanth SG, et al. (2004) Dynamics of pre-replication complex proteins during the cell division cycle. Philos Trans R Soc Lond B Biol Sci 359(1441):7-16 PMID: 15065651
- Semple JW and Duncker BP (2004) ORC-associated replication factors as biomarkers for cancer. Biotechnol Adv 22(8):621-31 PMID: 15364349
- Suter B, et al. (2004) The origin recognition complex links replication, sister chromatid cohesion and transcriptional silencing in Saccharomyces cerevisiae. Genetics 167(2):579-91 PMID: 15238513
- Takahashi N, et al. (2004) Analysis on origin recognition complex containing Orc5p with defective Walker A motif. J Biol Chem 279(9):8469-77 PMID: 14625297
- Takenaka H, et al. (2004) ADP-binding to origin recognition complex of Saccharomyces cerevisiae. J Mol Biol 340(1):29-37 PMID: 15184020
- Wilmes GM, et al. (2004) Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch. Genes Dev 18(9):981-91 PMID: 15105375
- Zannis-Hadjopoulos M, et al. (2004) Eucaryotic replication origin binding proteins. Front Biosci 9:2133-43 PMID: 15353275
- Araki Y, et al. (2003) Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability. Genes Cells 8(5):465-80 PMID: 12694535
- Burich R and Lei M (2003) Two bipartite NLSs mediate constitutive nuclear localization of Mcm10. Curr Genet 44(4):195-201 PMID: 13680157
- DePamphilis ML (2003) The 'ORC cycle': a novel pathway for regulating eukaryotic DNA replication. Gene 310:1-15 PMID: 12801628
- Grainge I, et al. (2003) Biochemical analysis of components of the pre-replication complex of Archaeoglobus fulgidus. Nucleic Acids Res 31(16):4888-98 PMID: 12907732
- Kneissl M, et al. (2003) Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. J Mol Biol 327(1):111-28 PMID: 12614612
- Palacios DeBeer MA, et al. (2003) Differential DNA affinity specifies roles for the origin recognition complex in budding yeast heterochromatin. Genes Dev 17(15):1817-22 PMID: 12897051
- Sharp JA, et al. (2003) The budding yeast silencing protein Sir1 is a functional component of centromeric chromatin. Genes Dev 17(19):2356-61 PMID: 12975325
- Devault A, et al. (2002) Identification of Tah11/Sid2 as the ortholog of the replication licensing factor Cdt1 in Saccharomyces cerevisiae. Curr Biol 12(8):689-94 PMID: 11967159
- Duncker BP, et al. (2002) An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing. Proc Natl Acad Sci U S A 99(25):16087-92 PMID: 12441400
- Du YC and Stillman B (2002) Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis. Cell 109(7):835-48 PMID: 12110181
- Gerbi SA, et al. (2002) Initiation of DNA replication in multicellular eukaryotes. J Struct Biol 140(1-3):17-30 PMID: 12490150
- Grünweller A and Ehrenhofer-Murray AE (2002) A novel yeast silencer. the 2mu origin of Saccharomyces cerevisiae has HST3-, MIG1- and SIR-dependent silencing activity. Genetics 162(1):59-71 PMID: 12242223
- Hart EA, et al. (2002) Fission yeast Cdc23 interactions with DNA replication initiation proteins. Curr Genet 41(5):342-8 PMID: 12185500
- Li CJ and DePamphilis ML (2002) Mammalian Orc1 protein is selectively released from chromatin and ubiquitinated during the S-to-M transition in the cell division cycle. Mol Cell Biol 22(1):105-16 PMID: 11739726
- Tadokoro R, et al. (2002) Scheduled conversion of replication complex architecture at replication origins of Saccharomyces cerevisiae during the cell cycle. J Biol Chem 277(18):15881-9 PMID: 11842092
- Takahashi N, et al. (2002) Functions of sensor 1 and sensor 2 regions of Saccharomyces cerevisiae Cdc6p in vivo and in vitro. J Biol Chem 277(18):16033-40 PMID: 11827963
- Watanabe K, et al. (2002) Involvement of RAD9-dependent damage checkpoint control in arrest of cell cycle, induction of cell death, and chromosome instability caused by defects in origin recognition complex in Saccharomyces cerevisiae. Eukaryot Cell 1(2):200-12 PMID: 12455955
- Wilmes GM and Bell SP (2002) The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formation. Proc Natl Acad Sci U S A 99(1):101-6 PMID: 11756674
- Zhang Z, et al. (2002) Structure and function of the BAH-containing domain of Orc1p in epigenetic silencing. EMBO J 21(17):4600-11 PMID: 12198162
- Bielinsky AK and Gerbi SA (2001) Where it all starts: eukaryotic origins of DNA replication. J Cell Sci 114(Pt 4):643-51 PMID: 11171369
- Bryant JA, et al. (2001) Origins and complexes: the initiation of DNA replication. J Exp Bot 52(355):193-202 PMID: 11283163
- Davis L, et al. (2001) The Saccharomyces cerevisiae MUM2 gene interacts with the DNA replication machinery and is required for meiotic levels of double strand breaks. Genetics 157(3):1179-89 PMID: 11238403
- Dhar SK, et al. (2001) Architecture of the human origin recognition complex. J Biol Chem 276(31):29067-71 PMID: 11395502
- Gardner KA and Fox CA (2001) The Sir1 protein's association with a silenced chromosome domain. Genes Dev 15(2):147-57 PMID: 11157772
- Giraldo R and Diaz-Orejas R (2001) Similarities between the DNA replication initiators of Gram-negative bacteria plasmids (RepA) and eukaryotes (Orc4p)/archaea (Cdc6p). Proc Natl Acad Sci U S A 98(9):4938-43 PMID: 11296251
- Jang SW, et al. (2001) Identification of Cdc6 protein domains involved in interaction with Mcm2 protein and Cdc4 protein in budding yeast cells. Biochem J 354(Pt 3):655-61 PMID: 11237870
- Klemm RD and Bell SP (2001) ATP bound to the origin recognition complex is important for preRC formation. Proc Natl Acad Sci U S A 98(15):8361-7 PMID: 11459976
- Lee JK, et al. (2001) The Schizosaccharomyces pombe origin recognition complex interacts with multiple AT-rich regions of the replication origin DNA by means of the AT-hook domains of the spOrc4 protein. Proc Natl Acad Sci U S A 98(24):13589-94 PMID: 11717425
- Lipford JR and Bell SP (2001) Nucleosomes positioned by ORC facilitate the initiation of DNA replication. Mol Cell 7(1):21-30 PMID: 11172708
- Nguyen VQ, et al. (2001) Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms. Nature 411(6841):1068-73 PMID: 11429609
- Pflumm MF and Botchan MR (2001) Orc mutants arrest in metaphase with abnormally condensed chromosomes. Development 128(9):1697-707 PMID: 11290306
- Rusché LN and Rine J (2001) Conversion of a gene-specific repressor to a regional silencer. Genes Dev 15(8):955-67 PMID: 11316790
- Shareef MM, et al. (2001) Drosophila heterochromatin protein 1 (HP1)/origin recognition complex (ORC) protein is associated with HP1 and ORC and functions in heterochromatin-induced silencing. Mol Biol Cell 12(6):1671-85 PMID: 11408576
- Sutton A, et al. (2001) A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex. Mol Cell Biol 21(10):3514-22 PMID: 11313477
- Theis JF and Newlon CS (2001) Two compound replication origins in Saccharomyces cerevisiae contain redundant origin recognition complex binding sites. Mol Cell Biol 21(8):2790-801 PMID: 11283258
- Vashee S, et al. (2001) Assembly of the human origin recognition complex. J Biol Chem 276(28):26666-73 PMID: 11323433
- Wang Y, et al. (2001) DNA replication forks pause at silent origins near the HML locus in budding yeast. Mol Cell Biol 21(15):4938-48 PMID: 11438651
- Wegrzyn A and Wegrzyn G (2001) Inheritance of the replication complex: a unique or common phenomenon in the control of DNA replication? Arch Microbiol 175(2):86-93 PMID: 11285745
- Weinreich M, et al. (2001) Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle. Proc Natl Acad Sci U S A 98(20):11211-7 PMID: 11572976
- Dhar SK and Dutta A (2000) Identification and characterization of the human ORC6 homolog. J Biol Chem 275(45):34983-8 PMID: 10945994
- Feng L, et al. (2000) Loss control of Mcm5 interaction with chromatin in cdc6-1 mutated in CDC-NTP motif. DNA Cell Biol 19(7):447-57 PMID: 10945234
- Kawasaki Y, et al. (2000) Interactions between Mcm10p and other replication factors are required for proper initiation and elongation of chromosomal DNA replication in Saccharomyces cerevisiae. Genes Cells 5(12):975-89 PMID: 11168584
- Lee DG and Bell SP (2000) ATPase switches controlling DNA replication initiation. Curr Opin Cell Biol 12(3):280-5 PMID: 10801458
- Lee DG, et al. (2000) Regulation of origin recognition complex conformation and ATPase activity: differential effects of single-stranded and double-stranded DNA binding. EMBO J 19(17):4774-82 PMID: 10970868
- Loebel D, et al. (2000) Localisation of the DmCdc45 DNA replication factor in the mitotic cycle and during chorion gene amplification. Nucleic Acids Res 28(20):3897-903 PMID: 11024168
- Mizushima T, et al. (2000) Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro. Genes Dev 14(13):1631-41 PMID: 10887157
- Seki T and Diffley JF (2000) Stepwise assembly of initiation proteins at budding yeast replication origins in vitro. Proc Natl Acad Sci U S A 97(26):14115-20 PMID: 11121019
- Sharma M, et al. (2000) Androgen receptor interacts with a novel MYST protein, HBO1. J Biol Chem 275(45):35200-8 PMID: 10930412
- Tatsumi Y, et al. (2000) Association of human origin recognition complex 1 with chromatin DNA and nuclease-resistant nuclear structures. J Biol Chem 275(8):5904-10 PMID: 10681582
- Zou L and Stillman B (2000) Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase. Mol Cell Biol 20(9):3086-96 PMID: 10757793
- Asano M and Wharton RP (1999) E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila. EMBO J 18(9):2435-48 PMID: 10228158
- Bielinsky AK and Gerbi SA (1999) Chromosomal ARS1 has a single leading strand start site. Mol Cell 3(4):477-86 PMID: 10230400
- Chuang RY and Kelly TJ (1999) The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks. Proc Natl Acad Sci U S A 96(6):2656-61 PMID: 10077566
- Costanzo V, et al. (1999) Protein kinase A is required for chromosomal DNA replication. Curr Biol 9(16):903-6 PMID: 10469595
- Duncker BP, et al. (1999) Cyclin B-cdk1 kinase stimulates ORC- and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts. Mol Cell Biol 19(2):1226-41 PMID: 9891057
- Ehrenhofer-Murray AE, et al. (1999) A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae. Genetics 153(3):1171-82 PMID: 10545450
- Gardner KA, et al. (1999) A region of the Sir1 protein dedicated to recognition of a silencer and required for interaction with the Orc1 protein in saccharomyces cerevisiae. Genetics 151(1):31-44 PMID: 9872946
- Hengstschläger M, et al. (1999) Cyclin-dependent kinases at the G1-S transition of the mammalian cell cycle. Mutat Res 436(1):1-9 PMID: 9878675
- Iizuka M and Stillman B (1999) Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein. J Biol Chem 274(33):23027-34 PMID: 10438470
- Lygerou Z and Nurse P (1999) The fission yeast origin recognition complex is constitutively associated with chromatin and is differentially modified through the cell cycle. J Cell Sci 112 ( Pt 21):3703-12 PMID: 10523506
- Moon KY, et al. (1999) Identification and reconstitution of the origin recognition complex from Schizosaccharomyces pombe. Proc Natl Acad Sci U S A 96(22):12367-72 PMID: 10535928
- Palacios DeBeer MA and Fox CA (1999) A role for a replicator dominance mechanism in silencing. EMBO J 18(13):3808-19 PMID: 10393196
- Pasero P, et al. (1999) A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication. Genes Dev 13(16):2159-76 PMID: 10465792
- Springer J, et al. (1999) Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex. Cytogenet Cell Genet 87(3-4):245-51 PMID: 10702681
- Springer J, et al. (1999) Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex. Chromosoma 108(4):243-9 PMID: 10460412
- Weinberger M, et al. (1999) Induction by adozelesin and hydroxyurea of origin recognition complex-dependent DNA damage and DNA replication checkpoints in Saccharomyces cerevisiae. J Biol Chem 274(50):35975-84 PMID: 10585487
- Bielinsky AK and Gerbi SA (1998) Discrete start sites for DNA synthesis in the yeast ARS1 origin. Science 279(5347):95-8 PMID: 9417033
- Dillin A and Rine J (1998) Roles for ORC in M phase and S phase. Science 279(5357):1733-7 PMID: 9497294
- Huang DW, et al. (1998) Distinct cytoplasmic and nuclear fractions of Drosophila heterochromatin protein 1: their phosphorylation levels and associations with origin recognition complex proteins. J Cell Biol 142(2):307-18 PMID: 9679132
- Ohtani K, et al. (1998) Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F. Oncogene 17(14):1777-85 PMID: 9778043
- Stone EM and Pillus L (1998) Silent chromatin in yeast: an orchestrated medley featuring Sir3p [corrected]. Bioessays 20(1):30-40 PMID: 9504045
- Tanaka T and Nasmyth K (1998) Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases. EMBO J 17(17):5182-91 PMID: 9724654
- Tugal T, et al. (1998) The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. J Biol Chem 273(49):32421-9 PMID: 9829972
- Zisimopoulou P, et al. (1998) Mouse homolog of the yeast origin recognition complex subunit ORC1 and chromosomal localization of the cognate mouse gene Orc1. Mol Gen Genet 260(2-3):295-9 PMID: 9862484
- Donovan S, et al. (1997) Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc Natl Acad Sci U S A 94(11):5611-6 PMID: 9159120
- Ehrenhofer-Murray AE, et al. (1997) The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function. Genetics 145(4):923-34 PMID: 9093847
- Fox CA, et al. (1997) The origin recognition complex, SIR1, and the S phase requirement for silencing. Science 276(5318):1547-51 PMID: 9171055
- Hardy CF (1997) Identification of Cdc45p, an essential factor required for DNA replication. Gene 187(2):239-46 PMID: 9099887
- Ishiai M, et al. (1997) Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22. Genomics 46(2):294-8 PMID: 9417919
- Landis G, et al. (1997) The k43 gene, required for chorion gene amplification and diploid cell chromosome replication, encodes the Drosophila homolog of yeast origin recognition complex subunit 2. Proc Natl Acad Sci U S A 94(8):3888-92 PMID: 9108074
- Lee DG and Bell SP (1997) Architecture of the yeast origin recognition complex bound to origins of DNA replication. Mol Cell Biol 17(12):7159-68 PMID: 9372948
- Liang C and Stillman B (1997) Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev 11(24):3375-86 PMID: 9407030
- Lin S and Kowalski D (1997) Functional equivalency and diversity of cis-acting elements among yeast replication origins. Mol Cell Biol 17(9):5473-84 PMID: 9271423
- Pak DT, et al. (1997) Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes. Cell 91(3):311-23 PMID: 9363940
- Quintana DG, et al. (1997) Identification of HsORC4, a member of the human origin of replication recognition complex. J Biol Chem 272(45):28247-51 PMID: 9353276
- Rowles A and Blow JJ (1997) Chromatin proteins involved in the initiation of DNA replication. Curr Opin Genet Dev 7(2):152-7 PMID: 9115430
- Theis JF and Newlon CS (1997) The ARS309 chromosomal replicator of Saccharomyces cerevisiae depends on an exceptional ARS consensus sequence. Proc Natl Acad Sci U S A 94(20):10786-91 PMID: 9380711
- Zou L, et al. (1997) CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication. Mol Cell Biol 17(2):553-63 PMID: 9001208
- Boscheron C, et al. (1996) Cooperation at a distance between silencers and proto-silencers at the yeast HML locus. EMBO J 15(9):2184-95 PMID: 8641284
- Carpenter PB, et al. (1996) Role for a Xenopus Orc2-related protein in controlling DNA replication. Nature 379(6563):357-60 PMID: 8552193
- Cocker JH, et al. (1996) An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature 379(6561):180-2 PMID: 8538771
- Coleman TR, et al. (1996) The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 87(1):53-63 PMID: 8858148
- Hardy CF (1996) Characterization of an essential Orc2p-associated factor that plays a role in DNA replication. Mol Cell Biol 16(4):1832-41 PMID: 8657159
- Hardy CF and Pautz A (1996) A novel role for Cdc5p in DNA replication. Mol Cell Biol 16(12):6775-82 PMID: 8943332
- Huang RY and Kowalski D (1996) Multiple DNA elements in ARS305 determine replication origin activity in a yeast chromosome. Nucleic Acids Res 24(5):816-23 PMID: 8600446
- Leatherwood J, et al. (1996) Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein. Nature 379(6563):360-3 PMID: 8552194
- Nasmyth K (1996) At the heart of the budding yeast cell cycle. Trends Genet 12(10):405-12 PMID: 8909137
- Ohtani K, et al. (1996) Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. Mol Cell Biol 16(12):6977-84 PMID: 8943353
- Romanowski P, et al. (1996) The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin. Curr Biol 6(11):1416-25 PMID: 8939603
- Santocanale C and Diffley JF (1996) ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae. EMBO J 15(23):6671-9 PMID: 8978693
- Takahara K, et al. (1996) Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L. Genomics 31(1):119-22 PMID: 8808289
- Wolf DA, et al. (1996) Disruption of re-replication control by overexpression of human ORC1 in fission yeast. J Biol Chem 271(51):32503-6 PMID: 8955071
- Bell SP, et al. (1995) The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing. Cell 83(4):563-8 PMID: 7585959
- Diffley JF, et al. (1995) Stepwise assembly of initiation complexes at budding yeast replication origins during the cell cycle. J Cell Sci Suppl 19:67-72 PMID: 8655649
- Ehrenhofer-Murray AE, et al. (1995) Separation of origin recognition complex functions by cross-species complementation. Science 270(5242):1671-4 PMID: 7502078
- Gavin KA, et al. (1995) Conserved initiator proteins in eukaryotes. Science 270(5242):1667-71 PMID: 7502077
- Gossen M, et al. (1995) A Drosophila homolog of the yeast origin recognition complex. Science 270(5242):1674-7 PMID: 7502079
- Liang C, et al. (1995) ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell 81(5):667-76 PMID: 7774008
- Loo S and Rine J (1995) Silencing and heritable domains of gene expression. Annu Rev Cell Dev Biol 11:519-48 PMID: 8689568
- Loo S, et al. (1995) The origin recognition complex in silencing, cell cycle progression, and DNA replication. Mol Biol Cell 6(6):741-56 PMID: 7579692
- Muzi-Falconi M and Kelly TJ (1995) Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex. Proc Natl Acad Sci U S A 92(26):12475-9 PMID: 8618924
- Rao H and Stillman B (1995) The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators. Proc Natl Acad Sci U S A 92(6):2224-8 PMID: 7892251
- Rowley A, et al. (1995) Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC. EMBO J 14(11):2631-41 PMID: 7781615
- Marahrens Y and Stillman B (1994) Replicator dominance in a eukaryotic chromosome. EMBO J 13(14):3395-400 PMID: 8045266
- Rao H, et al. (1994) Functional conservation of multiple elements in yeast chromosomal replicators. Mol Cell Biol 14(11):7643-51 PMID: 7935478
- Bell SP, et al. (1993) Yeast origin recognition complex functions in transcription silencing and DNA replication. Science 262(5141):1844-9 PMID: 8266072
- Foss M, et al. (1993) Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae. Science 262(5141):1838-44 PMID: 8266071
- Li JJ and Herskowitz I (1993) Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system. Science 262(5141):1870-4 PMID: 8266075
- Micklem G, et al. (1993) Yeast origin recognition complex is involved in DNA replication and transcriptional silencing. Nature 366(6450):87-9 PMID: 8232543
- Bell SP and Stillman B (1992) ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357(6374):128-34 PMID: 1579162
- Diffley JF and Cocker JH (1992) Protein-DNA interactions at a yeast replication origin. Nature 357(6374):169-72 PMID: 1579168