Protein abundance data, domains, shared domains with other proteins, protein sequence retrieval for various strains, sequence-based physico-chemical properties, protein modification sites, and external identifiers for the protein.
AlphaFold, developed by DeepMind, is an AI program that accurately predicts protein structures from amino acid sequences, enabling visualization of protein conformations. The predicted structures can be accessed through the Protein Data Bank (PDB) and AlphaFold Protein Structure Database.
Contains experimentally-derived protein half-life data obtained using stable isotope labeling by amino acids (SILAC) coupled with mass spectrometry. This section also contains protein abundance data for both untreated and treated cells obtained from over 20 studies. These data have been normalized and converted to a common unit of molecules per cell.
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Abundance (molecules/cell) | Media | Treatment | Treatment time | Fold Change | Visualization | Strain background | Original Reference | Reference |
---|---|---|---|---|---|---|---|---|
1394 | SD | 1 mM hydrogen peroxide | 1 hr | confocal microscopy evidence | S288C | Breker M, et al. (2013) | Ho B, et al. (2018) | |
3085 | YEPD | cell quiescence | 7 d | flow cytometry evidence | S288C | Davidson GS, et al. (2011) | Ho B, et al. (2018) | |
1809 | SD | untreated | quantitative mass spectrometry evidence | S288C | de Godoy LM, et al. (2008) | Ho B, et al. (2018) | ||
3676 | SD | 0.03% methyl methanesulfonate | 7 hr | wide-field microscopy evidence | S288C | Dénervaud N, et al. (2013) | Ho B, et al. (2018) | |
125 | YEPD | untreated | qualitative western immunoblotting evidence | S288C | Ghaemmaghami S, et al. (2003) | Ho B, et al. (2018) |
Collection of computationally identified domains and motifs, as determined by InterProScan analysis; includes protein coordinates for the domain, a domain Description, a Source and corresponding accession ID, and the number of S. cerevisiae genes that share the same domain.
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Protein Coordinates | Accession ID | Description | Source | No. of Genes with Domain |
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Visual representation of the locations of the domains within the protein, as listed in the Domains and Classification table. Each row displays the domain(s) derived from a different Source, with domains color-coded according to this Source.
Scroll over a domain to view its exact coordinates and its Description.
Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.
View all TFC3 alleles in SGD search
Protein sequence for the given gene in S288C and other strains, when available. Use the pull-down menu under "Strain" to select the sequence for a specific strain. The displayed sequence can be downloaded in FASTA format as a .txt file. Amino acids displayed in blue represent modification sites. More detailed evidence for these modification sites is presented in the Post-translational Modifications table, located just below the protein sequence.
This locus is not translated into a protein.
1 MVLTIYPDEL VQIVSDKIAS NKGKITLNQL WDISGKYFDL SDKKVKQFVL SCVILKKDIE
61 VYCDGAITTK NVTDIIGDAN HSYSVGITED SLWTLLTGYT KKESTIGNSA FELLLEVAKS
121 GEKGINTMDL AQVTGQDPRS VTGRIKKINH LLTSSQLIYK GHVVKQLKLK KFSHDGVDSN
181 PYINIRDHLA TIVEVVKRSK NGIRQIIDLK RELKFDKEKR LSKAFIAAIA WLDEKEYLKK
241 VLVVSPKNPA IKIRCVKYVK DIPDSKGSPS FEYDSNSADE DSVSDSKAAF EDEDLVEGLD
301 NFNATDLLQN QGLVMEEKED AVKNEVLLNR FYPLQNQTYD IADKSGLKGI STMDVVNRIT
361 GKEFQRAFTK SSEYYLESVD KQKENTGGYR LFRIYDFEGK KKFFRLFTAQ NFQKLTNAED
421 EISVPKGFDE LGKSRTDLKT LNEDNFVALN NTVRFTTDSD GQDIFFWHGE LKIPPNSKKT
481 PNKNKRKRQV KNSTNASVAG NISNPKRIKL EQHVSTAQEP KSAEDSPSSN GGTVVKGKVV
541 NFGGFSARSL RSLQRQRAIL KVMNTIGGVA YLREQFYESV SKYMGSTTTL DKKTVRGDVD
601 LMVESEKLGA RTEPVSGRKI IFLPTVGEDA IQRYILKEKD SKKATFTDVI HDTEIYFFDQ
661 TEKNRFHRGK KSVERIRKFQ NRQKNAKIKA SDDAISKKST SVNVSDGKIK RRDKKVSAGR
721 TTVVVENTKE DKTVYHAGTK DGVQALIRAV VVTKSIKNEI MWDKITKLFP NNSLDNLKKK
781 WTARRVRMGH SGWRAYVDKW KKMLVLAIKS EKISLRDVEE LDLIKLLDIW TSFDEKEIKR
841 PLFLYKNYEE NRKKFTLVRD DTLTHSGNDL AMSSMIQREI SSLKKTYTRK ISASTKDLSK
901 SQSDDYIRTV IRSILIESPS TTRNEIEALK NVGNESIDNV IMDMAKEKQI YLHGSKLECT
961 DTLPDILENR GNYKDFGVAF QYRCKVNELL EAGNAIVINQ EPSDISSWVL IDLISGELLN
1021 MDVIPMVRNV RPLTYTSRRF EIRTLTPPLI IYANSQTKLN TARKSAVKVP LGKPFSRLWV
1081 NGSGSIRPNI WKQVVTMVVN EIIFHPGITL SRLQSRCREV LSLHEISEIC KWLLERQVLI
1141 TTDFDGYWVN HNWYSIYEST *
* Blue amino acids indicate modification sites. More information below.
Modification sites for the protein in the selected strain, based on the presence of a residue in the specific strain, as inferred from experimental evidence.
25 entries for 17 sitesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
Site | Modification | Modifier | Reference |
---|---|---|---|
S268 | phosphorylated residue | Lanz MC, et al. (2021) PMID: 33491328 | |
S270 | phosphorylated residue | Lanz MC, et al. (2021) PMID: 33491328 | |
S275 | phosphorylated residue | Lanz MC, et al. (2021) PMID: 33491328 | |
S277 | phosphorylated residue | Chen YC, et al. (2018) PMID: 30516470 | |
S277 | phosphorylated residue | Swaney DL, et al. (2013) PMID: 23749301 | |
S277 | phosphorylated residue | Zhou X, et al. (2021) PMID: 33481703 | |
S277 | phosphorylated residue | Lanz MC, et al. (2021) PMID: 33491328 | |
S282 | phosphorylated residue | Zhou X, et al. (2021) PMID: 33481703 | |
S284 | phosphorylated residue | Zhou X, et al. (2021) PMID: 33481703 | |
S378 | phosphorylated residue | Lanz MC, et al. (2021) PMID: 33491328 |
Calculated protein properties, including amino acid composition, length, coding region calculations, and atomic composition.
Sort table using the arrow to the right of a column header to sort by that column; download all properties as a .txt file using the "Download Properties" button.
Amino Acid | Frequency | Percentage |
---|---|---|
A | 52 | 4.48 |
C | 7 | 0.60 |
D | 79 | 6.81 |
E | 73 | 6.29 |
F | 42 | 3.62 |
G | 59 | 5.09 |
H | 16 | 1.38 |
I | 87 | 7.50 |
K | 125 | 10.78 |
L | 97 | 8.36 |
M | 17 | 1.47 |
N | 66 | 5.69 |
P | 30 | 2.59 |
Q | 37 | 3.19 |
R | 64 | 5.52 |
S | 97 | 8.36 |
T | 75 | 6.47 |
V | 87 | 7.50 |
W | 15 | 1.29 |
Y | 35 | 3.02 |
Length (a.a): | 1160 |
Molecular Weight (Da): | 132146.8 |
Isoelectric Point (pl): | 9.93 |
Formula: | C5878H9512N1627O1775S24 |
Aliphatic Index: | 83.17 |
Instability Index: | 31.78 |
Codon Bias: | -0.03 |
Codon Adaptation Index: | 0.12 |
Frequence of Optimal Codons: | 0.42 |
Hydropathicity of Protein: | -0.51 |
Aromaticity Score: | 0.08 |
ALL Cys residues appear as half cystines: | 135025.0 |
NO Cys residues appear as half cystines: | 134650.0 |
Sort table using the arrow to the right of a column header to sort by that column; download all properties as a .txt file using the "Download Properties" button.
Atom | Frequency | Percentage |
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Data not found or not available for S288C
List of external identifiers for the protein from various database sources.
21 entries for 9 sourcesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
External ID | Source |
---|---|
orf19.3833 | CGD |
6739 | DIP |
170944 | GenBank/EMBL/DDBJ |
385245 | GenBank/EMBL/DDBJ |
6319317 | GenBank/EMBL/DDBJ |
L22015 | GenBank/EMBL/DDBJ |
AAC04956.1 | GenBank/EMBL/DDBJ |
AAA34378.1 | GenBank/EMBL/DDBJ |
M98261 | GenBank/EMBL/DDBJ |
464875 | GenBank/EMBL/DDBJ |
AGD | AnalogYeast | BLASTP at NCBI | CGD | FungiDB | PhylomeDB | PomBase | YGOB | YOGY
AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB
CYCLoPs | dHITS | LoQAtE | YeastGFP | YeastRC Public Images | YeastRGB | YPL+