SHP1 / YBL058W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

SHP1/YBL058W is a non-essential gene; null mutants are viable and exhibit a variety of phenotypic abnormalities, including decreased resistance to acid and alkaline pH, abnormal actin cytoskeleton morphology, decreased autophagy, abnormal bud morphology, decreased duration of cell cycle progression in the G1 phase, arrest at the G2/M phase transition, increased cell size, abnormal chromosome segregation, decreased chronological lifespan, increased cold sensitivity, abnormal colony appearance, increased colony sectoring, decreased competitive fitness, decreased endocytosis, decreased rate of fermentative growth, decreased freeze-thaw resistance, decreased hyperosmotic stress resistance, decreased ionic stress resistance, increased killer toxin resistance, decreased metal resistance, decreased oxidative stress resistance, decreased rate of respiratory growth, decreased reticulophagy, decreased sporulation, decreased telomere length, and decreased vegetative growth. Repressible mutants show arrested cell cycle progression in metaphase. Reduction of function mutants exhibit decreased heat sensitivity, increased osmotic stress resistance, and decreased vegetative growth. Note that the null mutant is inviable in strain W303, in contrast to S288C.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources