Phenotype Help

BOI1 / YBL085W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene; null mutant displays decreased competitive fitness in minimal medium; homozygous diploid null mutant has decreased oxidative stress resistance; null mutant displays increased resistance to treatment with bleomycin, camptothecin, cycloheximide and miconazole; overexpression results in a growth defect, increased cell size, a round morphology and an abnormal budding index with an increased quantity of unbudded cells; heterozygous diploid null is haploinsufficient

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

20 entries for 13 phenotypes


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PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
budding index: abnormal
classical geneticsoverexpressionS288CSopko R, et al. (2006) PMID:16455487
cell size: increased
classical geneticsoverexpressionS288CDetails: see Table S7 for more details
Sopko R, et al. (2006) PMID:16455487
cellular morphology: abnormal
classical geneticsoverexpressionS288CDetails: see Table S7 for more details
Sopko R, et al. (2006) PMID:16455487
cellular morphology: abnormal
classical genetics overexpressionOtherDetails: accumulation of large unbudded cells
Glomb O, et al. (2020) PMID:31964708
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: boi1-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.993
Breslow DK, et al. (2008) PMID:18622397
haploinsufficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: boi1-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: -0.0046
Pir P, et al. (2012) PMID:22244311
metal resistance: decreased
systematic mutation set null
Allele: boi1-Δ
S288C1.35 mM manganese(II) chlorideHernández RB, et al. (2019) PMID:31024033
mitotic recombination: decreased
systematic mutation set null
Allele: boi1-Δ
S288CDetails: spontaneous direct-repeat hypo-recombination identified using a high-throughput replica-pinning technique; recombination frequency of less than 33% compared to 56% for wt
Novarina D, et al. (2020) PMID:32265288
oxidative stress resistance: decreased
homozygous diploid, competitive growthnull
Allele: boi1-Δ
S288C3 mM hydrogen peroxideBrown JA, et al. (2006) PMID:16738548
replicative lifespan: increased
systematic mutation set null
Allele: boi1-Δ
S288CDetails: long-lived mutants, one standard deviation above the mean, were identified using an HTP sequencing-based yeast replicative lifespan screen (SEBYL), with pooled cells subject to four rounds of biotin-based sorting to enrich old vs young cells, followed by sequencing to ID mutants and abundance
Yu R, et al. (2021) PMID:33790287
Showing 1 to 10 of 20 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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