VMA2 / YBR127C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant is sensitive to metal ions such as Zn2+, Cd2+, and Ni2+, and accumulates reduced levels of inorganic polyphosphates; null mutant exhibits shortened chronological and replicative lifespan, is sensitive to oxidative stress, and shows earlier onset of mitochondrial dysfunction during aging; in large-scale studies, the null mutant shows reduced competitive fitness in several different media; homozygous null mutant diploid is sensitive to desiccation and freeze-thaw stress, requires myo-inositol, and fails to respire; null mutant is sensitive to a variety of chemicals

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources