SUP45 / YBR143C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Essential gene; mutations cause aberrant cell shape and sensitivity to heat, cold, hyperosmotic stress, caffeine, HU, paromomycin, or cycloheximide; ts mutation blocks cytokinesis at the restrictive temperature; mutation blocks respiratory growth; mutations confer increased resistance to K. lactis zymocin and increased accumulation of certain tRNAs; in large-scale studies, repression confers lower competitive fitness; conditional mutant displays chromosome instability at the semi-permissive temperature; overexpression causes slow growth and G1 phase arrest or delay; diploid heterozygous null mutant is sensitive to starvation and echinocandin, and displays haploinsufficiency

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources