Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
20 entries for 15 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| auxotrophy | classical genetics | null Allele: his7-Δ | Other | histidine | Kuenzler M, et al. (1993) PMID:8366040 | |
| chemical compound accumulation: increased | homozygous diploid, systematic mutation set glycogen accumulation in diploid mutant strains grown in microtiter plates | null Allele: his7-Δ | S288C | glycogen | Wilson WA, et al. (2002) PMID:12096123 | |
| chemical compound accumulation: increased | classical genetics | unspecified | Other | 1-(phosphoribosyl)imidazolecarboxamide | Details: indicative of a defect in histidine biosynthesis | FINK GR (1964) PMID:14190241 |
| competitive fitness: increased | systematic mutation set | null Allele: his7-Δ | S288C | Media: synthetic complete medium, SC | Qian W, et al. (2012) PMID:23103169 | |
| endocytosis: decreased | systematic mutation set | null Allele: his7-Δ | S288C | Details: defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2 | Burston HE, et al. (2009) PMID:19506040 | |
| haploproficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: his7-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: 0.0046 | Pir P, et al. (2012) PMID:22244311 | |
| heat sensitivity: increased | homozygous diploid, systematic mutation set pooled screening for fitness defects at 37 deg C relative to 30 deg C | null Allele: his7-Δ | S288C | Temperature: elevated temperature, 37 °C | Sinha H, et al. (2008) PMID:18780730 | |
| metal resistance: decreased | classical genetics | unspecified | Other | 2.4 mM copper(II) sulfate | Details: also sensitive to cobalt and nickel; sensitivity affected by pH | Pearce DA and Sherman F (1999) PMID:10438744 |
| mitotic recombination: decreased | systematic mutation set | null Allele: his7-Δ | S288C | Details: spontaneous direct-repeat hypo-recombination identified using a high-throughput replica-pinning technique; recombination frequency of less than 33% compared to 56% for wt | Novarina D, et al. (2020) PMID:32265288 | |
| oxidative stress resistance: increased | competitive growth | null Allele: his7-Δ | S288C | 1 mM paraquat | Helsen J, et al. (2020) PMID:32658971 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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