Interaction Help

GCN4 / YEL009C Interactions

Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference. Experimental details, phenotype, modification, and multiple mutant information are included when available.


Summary
Gcn4p interacts physically with proteins involved in transcription; GCN4 interacts genetically with genes involved in transcription

Source: All physical and genetic interaction annotations listed in SGD are curated by BioGRID.

Genetic Interactions

An interaction is defined as an experimentally observed physical or genetic interaction between two genes. There may be more than one row listed for the same interactor if the interaction between it and the given gene was observed in separate studies. All interactions listed in SGD are curated by BioGRID.


Genetic Interactions

Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.

Interactor Interactor Allele Assay Annotation Action Phenotype SGA score P-value Source Reference

Physical Interactions

An interaction is defined as an experimentally observed physical or genetic interaction between two genes. There may be more than one row listed for the same interactor if the interaction between it and the given gene was observed in separate studies. All interactions listed in SGD are curated by BioGRID.


Physical Interactions 148 entries for 74 genes

Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.

InteractorAssayAnnotationActionModificationReference
ADA2Affinity Capture-Westernmanually curatedBaitNo ModificationNatarajan K, et al. (1998) PMID:9844640
ADA2Reconstituted Complexmanually curatedHitNo ModificationBarlev NA, et al. (1995) PMID:7642611
ADA2Reconstituted Complexmanually curatedBaitNo ModificationUtley RT, et al. (1998) PMID:9697775
ADA2Affinity Capture-Westernmanually curatedBaitNo ModificationDrysdale CM, et al. (1998) PMID:9488488

Split-ubiquitin assays were performed.

AHC1PCAmanually curatedBaitNo ModificationLim MK, et al. (2007) PMID:17919657
AHC1Two-hybridmanually curatedHitNo ModificationChen Y, et al. (2023) PMID:37099808
ARP7Affinity Capture-Westernmanually curatedBaitNo ModificationNeely KE, et al. (1999) PMID:10549297

Split-ubiquitin assays were performed.

CCL1PCAmanually curatedBaitNo ModificationLim MK, et al. (2007) PMID:17919657
CDC28PCAmanually curatedHitNo ModificationEar PH, et al. (2013) PMID:24019491

A refined two-hybrid system designed to inhibit ubiquitination of substrates was used to screen for substrates of the SCF-Cdc4 complex.

CDC4Two-hybridmanually curatedHitNo ModificationKishi T, et al. (2008) PMID:18787112
Showing 1 to 10 of 148 entries

Interaction Network

This diagram displays physical (purple lines) and genetic (green lines) interactions between the given gene (yellow circle) and its interactors (gray circles) based on the number of experiments supporting each interaction (adjustable using the slider at the bottom). Interactions between the interactors for a given gene are also shown.


Reset

Click on a gene to go to its specific page within SGD; drag any of the gene objects around within the visualization for easier viewing; filter by interaction type (genetic or physical) using the radio buttons; click “Reset” to automatically redraw the diagram; filter the number of interactors displayed by adjusting the number of experiments supporting a gene's interaction with the given gene by clicking anywhere on the slider bar or dragging the tab to the desired filter number.

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Resources


BioGRID | CYC2008 | DIP | GeneMANIA | IMP | InterologFinder | ModelArchive | TheCellMap | YeastRC Two-Hybrid

GLN3