RAD4 / YER162C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

RAD4/YER162C is a non-essential gene in reference strain S288C. Null mutants are viable and exhibit several phenotypic defects including increased mitotic recombination and mutation frequency, decreased chronological lifespan, reduced competitive fitness, and significant sensitivity to UV radiation, indicating that RAD4 plays a significant role in maintaining genomic stability and cell health by facilitating proper DNA repair mechanisms. Reduced-function mutants show increased mutation frequency and decreased UV resistance, further confirming the gene's importance in DNA repair and the cellular response to UV damage. These observations underscore the essential role of RAD4 in preserving genomic integrity and ensuring effective DNA repair, although it is not essential for basic survival under standard conditions.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources