PRS3 / YHL011C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

PRS3/YHL011C is a non-essential gene; null mutants are viable, slow-growing, and exhibit a variety of phenotypic abnormalities including decreased budding index and abnormal budding pattern, indicating disruptions in cell division; increased duration of cell cycle progression in G1, suggesting delays in cell cycle progression; abnormal cell shape and cellular morphology, and decreased cell size, indicating alterations in growth regulation; diminished competitive fitness, making these mutants less viable in competitive environments; decreased desiccation resistance, making them more vulnerable to dry conditions; slow fermentative growth, indicating impaired energy production under anaerobic conditions, and decreased respiratory growth, indicating impaired energy production under aerobic conditions; decreased hyperosmotic stress resistance and innate thermotolerance, suggesting heightened sensitivity to osmotic and temperature stress; decreased killer toxin resistance, making these mutants more susceptible to certain toxins; reduced sporulation efficiency, affecting reproductive success; decreased telomere length, which may impact chromosome stability and cellular aging; and decreased UV resistance, making these mutants more vulnerable to UV-induced damage.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources