SOD2 / YHR008C Overview
- Standard Name
- SOD2 1
- Systematic Name
- YHR008C
- SGD ID
- SGD:S000001050
- Feature Type
- ORF , Verified
- Description
- Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 can also complement when targeted to the mitochondrial matrix 2 3 4 5
- Name Description
- SuperOxide Dismutase 2
- Comparative Info
-
Sequence
The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.
Analyze Sequence
S288C only
BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species
BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi
S288C vs. other strains
Protein
Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.
- Length (a.a.)
- 233
- Mol. Weight (Da)
- 25776.4
- Isoelectric Point
- 8.87
- Median Abundance (molecules/cell)
- 11463 +/- 6095
- Half-life (hr)
- 7.8
Alleles
Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.
View all SOD2 alleles in SGD search
Gene Ontology
GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.
- Summary
- Mitochondrial manganese superoxide oxidoreductase involved in the metabolism of reactive oxygen species, cell aging, and the response of non-dividing cells oxidative stress
View computational annotations
Molecular Function
- Manually Curated
- enables superoxide dismutase activity (IDA)
Biological Process
- Manually Curated
- involved in reactive oxygen species metabolic process (IMP)
Cellular Component
- Manually Curated
- located in mitochondrial matrix (IDA)
- located in mitochondrion (HDA, IDA)
Pathways
Phenotype
Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.
- Summary
- Non-essential gene; null mutant displays a respiratory growth defect, increased apoptosis, and decreased chronological and replicative lifespan, null mutant is sensitive to a variety of environmental stresses including oxidative stress, desiccation, heat, ionic stress, and a variety of chemicals; in large-scale studies the null mutant displays reduced competitive fitness and altered resistance to a variety of chemicals
Classical Genetics
- null
- apoptosis: increased
- chemical compound accumulation: increased
- chronological lifespan: decreased
- chronological lifespan: increased
- desiccation resistance: decreased
- entry into G0 (stationary phase): decreased
- heat sensitivity: increased
- ionic stress resistance: decreased
- metal resistance: decreased
- metal resistance: increased
- necrotic cell death: increased
- oxidative stress resistance: decreased
- prion formation: increased
- protein activity: decreased
- replicative lifespan: decreased
- resistance to chemicals: decreased
- respiratory growth: decreased
- respiratory metabolism: decreased
- sporulation: decreased
- stress resistance: decreased
- survival rate in stationary phase: decreased
- toxin resistance: decreased
- viability: decreased
- overexpression
- repressible
- null
- alkaline pH resistance: decreased
- budding index: decreased
- chemical compound accumulation: abnormal
- chemical compound accumulation: decreased
- chemical compound accumulation: increased
- chronological lifespan: decreased
- competitive fitness: decreased
- heat sensitivity: increased
- metal resistance: increased
- mitochondrial morphology: abnormal
- oxidative stress resistance: decreased
- resistance to chemicals: decreased
- resistance to chemicals: increased
- respiratory growth: absent
- respiratory growth: decreased rate
- sporulation: absent
- starvation resistance: decreased
- toxin resistance: decreased
- transposable element transposition: decreased
- utilization of carbon source: decreased
- vegetative growth: decreased
- viable
Large-scale Survey
Disease
Disease Annotations consist of three mandatory components: a gene product, a term from the Disease Ontology (DO) controlled vocabulary and an evidence code. SGD provides manually curated DO Annotations derived from the literature. Click "Disease Details" to view all Disease information and evidence for this locus as well as diseases it shares with other genes.
- Summary
- Yeast SOD2 is homologous to human SOD2, and has been used to study Alzheimer’s and Parkinson’s diseases as well as some types of cancers
Manually Curated
- Alzheimer's disease (ISS, IMP)
- cancer (ISS, IMP)
- Parkinson's disease (ISS, IMP)
Interaction
Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.
308 total interactions for 255 unique genes
Physical Interactions
- Affinity Capture-MS: 27
- Affinity Capture-RNA: 7
- Co-crystal Structure: 1
- Co-purification: 1
- PCA: 2
- Reconstituted Complex: 6
Genetic Interactions
- Dosage Rescue: 8
- Negative Genetic: 182
- Phenotypic Enhancement: 12
- Phenotypic Suppression: 14
- Positive Genetic: 21
- Synthetic Growth Defect: 19
- Synthetic Lethality: 3
- Synthetic Rescue: 5
Regulation
The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.
- Regulators
- 15
- Targets
- 0
Expression
Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.
Summary Paragraph
A summary of the locus, written by SGD Biocurators following a thorough review of the literature. Links to gene names and curated GO terms are included within the Summary Paragraphs.
Last Updated: 2008-06-25
Literature
All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.