Phenotype Help

DAP2 / YHR028C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene; in systematic studies, null mutation causes slightly reduced competitive fitness and decreased growth under anaerobic conditions

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

14 entries for 9 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
anaerobic growth: decreased
systematic mutation setnull
Allele: dap2-Δ
S288CTreatment: anoxia
Details: poor growth as indicated by measurements of colony size
Samanfar B, et al. (2013) PMID:23467670
chromosome/plasmid maintenance: decreased
heterozygous diploid, systematic mutation setnull
Allele: dap2-Δ
S288CAssay: diploid bimater (BiM) assay
Details: haploinsufficiency results in chromosome instability (CIN); scored >= 2 standard deviations above the mean
Choy JS, et al. (2013) PMID:23825022
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: dap2-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.954
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: decreased
homozygous diploid, competitive growthnull
Allele: dap2-Δ
S288CTreatment: conditions that mimic Phase II of a batch fermentation, equivalent to ~22 hours after inoculation of a batch fermentation
Novo M, et al. (2013) PMID:24040173
haploproficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: dap2-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: 0.0037
Pir P, et al. (2012) PMID:22244311
resistance to chemicals: decreased
systematic mutation setnull
Allele: dap2-Δ
S288C CG-1521Gaupel AC, et al. (2014) PMID:24968945
resistance to chemicals: decreased
heterozygous diploid, systematic mutation set null
Allele: dap2-Δ
S288C20 μg/mL actinomycin DLum PY, et al. (2004) PMID:14718172
resistance to chemicals: decreased
heterozygous diploid, systematic mutation set null
Allele: dap2-Δ
S288C3 μg/mL doxorubicinLum PY, et al. (2004) PMID:14718172
resistance to chemicals: decreased
heterozygous diploid, systematic mutation set null
Allele: dap2-Δ
S288C30 μg/mL gemfibrozilLum PY, et al. (2004) PMID:14718172
resistance to chemicals: decreased
systematic mutation set null
Allele: dap2-Δ
S288C0.2 mM 2,4-dinitrophenolDetails: increased sensitivity to the IC25 concentration of 2,4-DNP relative to wt
Johnston NR, et al. (2020) PMID:32670247
Showing 1 to 10 of 14 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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