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SMF2 / YHR050W Literature
All manually curated literature for the specified gene, organized by relevance to the gene and by
association with specific annotations to the gene in SGD. SGD gathers references via a PubMed search for
papers whose titles or abstracts contain “yeast” or “cerevisiae;” these papers are reviewed manually and
linked to relevant genes and literature topics by SGD curators.
Primary Literature
Literature that either focuses on the gene or contains information about function, biological role,
cellular location, phenotype, regulation, structure, or disease homologs in other species for the gene
or gene product.
No primary literature curated.
Download References (.nbib)
- Qiu C, et al. (2024) Thiolutin has complex effects in vivo but is a direct inhibitor of RNA polymerase II in vitro. Nucleic Acids Res 52(5):2546-2564 PMID:38214235
- Nicastro R, et al. (2022) Manganese is a physiologically relevant TORC1 activator in yeast and mammals. Elife 11 PMID:35904415
- Sun GL, et al. (2019) Designing yeast as plant-like hyperaccumulators for heavy metals. Nat Commun 10(1):5080 PMID:31704944
- Thines L, et al. (2018) The yeast protein Gdt1p transports Mn2+ ions and thereby regulates manganese homeostasis in the Golgi. J Biol Chem 293(21):8048-8055 PMID:29632074
- García-Rodríguez N, et al. (2015) Manganese redistribution by calcium-stimulated vesicle trafficking bypasses the need for P-type ATPase function. J Biol Chem 290(15):9335-47 PMID:25713143
- Bolden S, et al. (2013) Structure-activity relationship (SAR) and preliminary mode of action studies of 3-substituted benzylthioquinolinium iodide as anti-opportunistic infection agents. Eur J Med Chem 70:130-42 PMID:24141203
- McNaughton RL, et al. (2010) Probing in vivo Mn2+ speciation and oxidative stress resistance in yeast cells with electron-nuclear double resonance spectroscopy. Proc Natl Acad Sci U S A 107(35):15335-9 PMID:20702768
- Au C, et al. (2009) SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans. PLoS One 4(11):e7792 PMID:19924247
- Jensen LT, et al. (2009) Down-regulation of a manganese transporter in the face of metal toxicity. Mol Biol Cell 20(12):2810-9 PMID:19369420
- Reddi AR, et al. (2009) The overlapping roles of manganese and Cu/Zn SOD in oxidative stress protection. Free Radic Biol Med 46(2):154-62 PMID:18973803
- Ruotolo R, et al. (2008) Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast. Genome Biol 9(4):R67 PMID:18394190
- Techau ME, et al. (2007) Evolution of differences in transport function in Slc11a family members. J Biol Chem 282(49):35646-56 PMID:17932044
- Jensen LT, et al. (2003) The Saccharomyces cerevisiae high affinity phosphate transporter encoded by PHO84 also functions in manganese homeostasis. J Biol Chem 278(43):42036-40 PMID:12923174
- I Bannon D, et al. (2002) Uptake of lead and iron by divalent metal transporter 1 in yeast and mammalian cells. Biochem Biophys Res Commun 295(4):978-84 PMID:12127992
- Portnoy ME, et al. (2002) The distinct methods by which manganese and iron regulate the Nramp transporters in yeast. Biochem J 362(Pt 1):119-24 PMID:11829747
- Reeve I, et al. (2002) Overexpression, purification, and site-directed spin labeling of the Nramp metal transporter from Mycobacterium leprae. Proc Natl Acad Sci U S A 99(13):8608-13 PMID:12077319
- Luk EE and Culotta VC (2001) Manganese superoxide dismutase in Saccharomyces cerevisiae acquires its metal co-factor through a pathway involving the Nramp metal transporter, Smf2p. J Biol Chem 276(50):47556-62 PMID:11602606
- Cohen A, et al. (2000) The family of SMF metal ion transporters in yeast cells. J Biol Chem 275(43):33388-94 PMID:10930410
- Portnoy ME, et al. (2000) Saccharomyces cerevisiae expresses three functionally distinct homologues of the nramp family of metal transporters. Mol Cell Biol 20(21):7893-902 PMID:11027260
- Chen XZ, et al. (1999) Yeast SMF1 mediates H(+)-coupled iron uptake with concomitant uncoupled cation currents. J Biol Chem 274(49):35089-94 PMID:10574989
- Liu XF, et al. (1997) Negative control of heavy metal uptake by the Saccharomyces cerevisiae BSD2 gene. J Biol Chem 272(18):11763-9 PMID:9115231
- Pinner E, et al. (1997) Functional complementation of the yeast divalent cation transporter family SMF by NRAMP2, a member of the mammalian natural resistance-associated macrophage protein family. J Biol Chem 272(46):28933-8 PMID:9360964
- Cellier M, et al. (1995) Nramp defines a family of membrane proteins. Proc Natl Acad Sci U S A 92(22):10089-93 PMID:7479731
- West AH, et al. (1992) Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein. J Biol Chem 267(34):24625-33 PMID:1447206
Related Literature
Genes that share literature (indicated by the purple circles) with the specified gene (indicated by yellow circle).
Reset
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Additional Literature
Papers that show experimental evidence for the gene or describe homologs in other species, but
for which the gene is not the paper’s principal focus.
No additional literature curated.
Download References (.nbib)
- Lanz MC, et al. (2021) In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep 22(2):e51121 PMID:33491328
- Trilisenko L, et al. (2019) The Reduced Level of Inorganic Polyphosphate Mobilizes Antioxidant and Manganese-Resistance Systems in Saccharomyces cerevisiae. Cells 8(5) PMID:31096715
- Hou YK, et al. (2018) LiMn0.8Fe0.2PO4/Carbon Nanospheres@Graphene Nanoribbons Prepared by the Biomineralization Process as the Cathode for Lithium-Ion Batteries. ACS Appl Mater Interfaces 10(19):16500-16510 PMID:29693376
- Mori T, et al. (2018) Functional characterization of the manganese transporter smf2 homologue gene, PsMnt, of Phanerochaete sordida YK-624 via homologous overexpression. FEMS Microbiol Lett 365(8) PMID:29566232
- Alejandro S, et al. (2017) Intracellular Distribution of Manganese by the Trans-Golgi Network Transporter NRAMP2 Is Critical for Photosynthesis and Cellular Redox Homeostasis. Plant Cell 29(12):3068-3084 PMID:29180598
- Vázquez M, et al. (2015) Participation of divalent cation transporter DMT1 in the uptake of inorganic mercury. Toxicology 331:119-24 PMID:25772431
- Barghash A and Helms V (2013) Transferring functional annotations of membrane transporters on the basis of sequence similarity and sequence motifs. BMC Bioinformatics 14:343 PMID:24283849
- Moreno-Cermeño A, et al. (2010) Frataxin depletion in yeast triggers up-regulation of iron transport systems before affecting iron-sulfur enzyme activities. J Biol Chem 285(53):41653-64 PMID:20956517
- Naranuntarat A, et al. (2009) The interaction of mitochondrial iron with manganese superoxide dismutase. J Biol Chem 284(34):22633-40 PMID:19561359
- De Hertogh B, et al. (2006) Emergence of species-specific transporters during evolution of the hemiascomycete phylum. Genetics 172(2):771-81 PMID:16118182
- Diffels JF, et al. (2006) Heavy metal transporters in Hemiascomycete yeasts. Biochimie 88(11):1639-49 PMID:17011109
- Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 PMID:16823961
- Takahashi T, et al. (2005) A novel role for Bsd2 in the resistance of yeast to adriamycin. J Cell Physiol 202(1):100-4 PMID:15389553
- Yang M, et al. (2005) Manganese toxicity and Saccharomyces cerevisiae Mam3p, a member of the ACDP (ancient conserved domain protein) family. Biochem J 386(Pt 3):479-87 PMID:15498024
- Cohen A, et al. (2003) The first external loop of the metal ion transporter DCT1 is involved in metal ion binding and specificity. Proc Natl Acad Sci U S A 100(19):10694-9 PMID:12954986
- Lam-Yuk-Tseung S, et al. (2003) Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6. Blood 101(9):3699-707 PMID:12522007
- Sickmann A, et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 PMID:14576278
- Emerson LR, et al. (2002) Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae. Antimicrob Agents Chemother 46(3):787-96 PMID:11850263
- Mai B and Breeden L (2000) CLN1 and its repression by Xbp1 are important for efficient sporulation in budding yeast. Mol Cell Biol 20(2):478-87 PMID:10611226
- Thomine S, et al. (2000) Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes. Proc Natl Acad Sci U S A 97(9):4991-6 PMID:10781110
- Korshunova YO, et al. (1999) The IRT1 protein from Arabidopsis thaliana is a metal transporter with a broad substrate range. Plant Mol Biol 40(1):37-44 PMID:10394943
- Li L and Kaplan J (1998) Defects in the yeast high affinity iron transport system result in increased metal sensitivity because of the increased expression of transporters with a broad transition metal specificity. J Biol Chem 273(35):22181-7 PMID:9712830
Reviews
No reviews curated.
Gene Ontology Literature
Paper(s) associated with one or more GO (Gene Ontology) terms in SGD for the specified gene.
No gene ontology literature curated.
Download References (.nbib)
- García-Rodríguez N, et al. (2015) Manganese redistribution by calcium-stimulated vesicle trafficking bypasses the need for P-type ATPase function. J Biol Chem 290(15):9335-47 PMID:25713143
- Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 PMID:16823961
- Sickmann A, et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 PMID:14576278
- Luk EE and Culotta VC (2001) Manganese superoxide dismutase in Saccharomyces cerevisiae acquires its metal co-factor through a pathway involving the Nramp metal transporter, Smf2p. J Biol Chem 276(50):47556-62 PMID:11602606
- Chen XZ, et al. (1999) Yeast SMF1 mediates H(+)-coupled iron uptake with concomitant uncoupled cation currents. J Biol Chem 274(49):35089-94 PMID:10574989
- Liu XF, et al. (1997) Negative control of heavy metal uptake by the Saccharomyces cerevisiae BSD2 gene. J Biol Chem 272(18):11763-9 PMID:9115231
Phenotype Literature
Paper(s) associated with one or more pieces of classical phenotype evidence in SGD for the specified gene.
No phenotype literature curated.
Download References (.nbib)
- García-Rodríguez N, et al. (2015) Manganese redistribution by calcium-stimulated vesicle trafficking bypasses the need for P-type ATPase function. J Biol Chem 290(15):9335-47 PMID:25713143
- Ruotolo R, et al. (2008) Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast. Genome Biol 9(4):R67 PMID:18394190
- Jensen LT, et al. (2003) The Saccharomyces cerevisiae high affinity phosphate transporter encoded by PHO84 also functions in manganese homeostasis. J Biol Chem 278(43):42036-40 PMID:12923174
- Cohen A, et al. (2000) The family of SMF metal ion transporters in yeast cells. J Biol Chem 275(43):33388-94 PMID:10930410
Interaction Literature
Paper(s) associated with evidence supporting a physical or genetic interaction between the
specified gene and another gene in SGD. Currently, all interaction evidence is obtained from
BioGRID.
No interaction literature curated.
Download References (.nbib)
- Carey SB, et al. (2023) A synthetic genetic array screen for interactions with the RNA helicase DED1 during cell stress in budding yeast. G3 (Bethesda) 13(1) PMID:36409020
- Nicastro R, et al. (2022) Manganese is a physiologically relevant TORC1 activator in yeast and mammals. Elife 11 PMID:35904415
- Sanders E, et al. (2020) Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of the Saccharomyces cerevisiae RecQ Helicases Hrq1 and Sgs1. G3 (Bethesda) 10(12):4359-4368 PMID:33115720
- Miller JE, et al. (2018) Genome-Wide Mapping of Decay Factor-mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4. G3 (Bethesda) 8(1):315-330 PMID:29158339
- Jungfleisch J, et al. (2017) A novel translational control mechanism involving RNA structures within coding sequences. Genome Res 27(1):95-106 PMID:27821408
- She R, et al. (2017) Comprehensive and quantitative mapping of RNA-protein interactions across a transcribed eukaryotic genome. Proc Natl Acad Sci U S A 114(14):3619-3624 PMID:28325876
- Shulist K, et al. (2017) Interrogation of γ-tubulin alleles using high-resolution fitness measurements reveals a distinct cytoplasmic function in spindle alignment. Sci Rep 7(1):11398 PMID:28900268
- Babour A, et al. (2016) The Chromatin Remodeler ISW1 Is a Quality Control Factor that Surveys Nuclear mRNP Biogenesis. Cell 167(5):1201-1214.e15 PMID:27863241
- Costanzo M, et al. (2016) A global genetic interaction network maps a wiring diagram of cellular function. Science 353(6306) PMID:27708008
- Lapointe CP, et al. (2015) Protein-RNA networks revealed through covalent RNA marks. Nat Methods 12(12):1163-70 PMID:26524240
- Porter DF, et al. (2015) Target selection by natural and redesigned PUF proteins. Proc Natl Acad Sci U S A 112(52):15868-73 PMID:26668354
- Atencio D, et al. (2014) The yeast Ess1 prolyl isomerase controls Swi6 and Whi5 nuclear localization. G3 (Bethesda) 4(3):523-37 PMID:24470217
- Vazquez HM, et al. (2014) Cdc1 removes the ethanolamine phosphate of the first mannose of GPI anchors and thereby facilitates the integration of GPI proteins into the yeast cell wall. Mol Biol Cell 25(21):3375-88 PMID:25165136
- Snider J, et al. (2013) Mapping the functional yeast ABC transporter interactome. Nat Chem Biol 9(9):565-72 PMID:23831759
- Sharifpoor S, et al. (2012) Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Genome Res 22(4):791-801 PMID:22282571
- Costanzo M, et al. (2010) The genetic landscape of a cell. Science 327(5964):425-31 PMID:20093466
- McNaughton RL, et al. (2010) Probing in vivo Mn2+ speciation and oxidative stress resistance in yeast cells with electron-nuclear double resonance spectroscopy. Proc Natl Acad Sci U S A 107(35):15335-9 PMID:20702768
- Techau ME, et al. (2007) Evolution of differences in transport function in Slc11a family members. J Biol Chem 282(49):35646-56 PMID:17932044
- Miller JP, et al. (2005) Large-scale identification of yeast integral membrane protein interactions. Proc Natl Acad Sci U S A 102(34):12123-8 PMID:16093310
- Toh-e A and Oguchi T (2002) Genetic characterization of genes encoding enzymes catalyzing addition of phospho-ethanolamine to the glycosylphosphatidylinositol anchor in Saccharomyces cerevisiae. Genes Genet Syst 77(5):309-22 PMID:12441642
- Luk EE and Culotta VC (2001) Manganese superoxide dismutase in Saccharomyces cerevisiae acquires its metal co-factor through a pathway involving the Nramp metal transporter, Smf2p. J Biol Chem 276(50):47556-62 PMID:11602606
- Liu XF, et al. (1997) Negative control of heavy metal uptake by the Saccharomyces cerevisiae BSD2 gene. J Biol Chem 272(18):11763-9 PMID:9115231
- West AH, et al. (1992) Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein. J Biol Chem 267(34):24625-33 PMID:1447206
Regulation Literature
Paper(s) associated with one or more pieces of regulation evidence in SGD, as found on the
Regulation page.
No regulation literature curated.
Post-translational Modifications Literature
Paper(s) associated with one or more pieces of post-translational modifications evidence in SGD.
No post-translational modifications literature curated.
High-Throughput Literature
Paper(s) associated with one or more pieces of high-throughput evidence in SGD.
No high-throughput literature curated.
Download References (.nbib)
- Grosjean N, et al. (2023) Yeast Deletomics to Uncover Gadolinium Toxicity Targets and Resistance Mechanisms. Microorganisms 11(8) PMID:37630673
- Yu R, et al. (2021) Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism. Nat Commun 12(1):1981 PMID:33790287
- Helsen J, et al. (2020) Gene Loss Predictably Drives Evolutionary Adaptation. Mol Biol Evol 37(10):2989-3002 PMID:32658971
- Grosjean N, et al. (2018) Global Deletome Profile of Saccharomyces cerevisiae Exposed to the Technology-Critical Element Yttrium. Front Microbiol 9:2005 PMID:30233513
- Chakrabortee S, et al. (2016) Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits. Cell 167(2):369-381.e12 PMID:27693355
- Hoepfner D, et al. (2014) High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions. Microbiol Res 169(2-3):107-20 PMID:24360837
- Ostrow AZ, et al. (2014) Fkh1 and Fkh2 bind multiple chromosomal elements in the S. cerevisiae genome with distinct specificities and cell cycle dynamics. PLoS One 9(2):e87647 PMID:24504085
- VanderSluis B, et al. (2014) Broad metabolic sensitivity profiling of a prototrophic yeast deletion collection. Genome Biol 15(4):R64 PMID:24721214
- Huang Z, et al. (2013) A functional variomics tool for discovering drug-resistance genes and drug targets. Cell Rep 3(2):577-85 PMID:23416056
- Marek A and Korona R (2013) Restricted pleiotropy facilitates mutational erosion of major life-history traits. Evolution 67(11):3077-86 PMID:24151994
- Zhao Y, et al. (2013) Activation of calcineurin is mainly responsible for the calcium sensitivity of gene deletion mutations in the genome of budding yeast. Genomics 101(1):49-56 PMID:23026396
- Armakola M, et al. (2012) Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nat Genet 44(12):1302-9 PMID:23104007
- Douglas AC, et al. (2012) Functional analysis with a barcoder yeast gene overexpression system. G3 (Bethesda) 2(10):1279-89 PMID:23050238
- Qian W, et al. (2012) The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast. Cell Rep 2(5):1399-410 PMID:23103169
- Yu D, et al. (2012) High-resolution genome-wide scan of genes, gene-networks and cellular systems impacting the yeast ionome. BMC Genomics 13:623 PMID:23151179
- Venters BJ, et al. (2011) A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol Cell 41(4):480-92 PMID:21329885
- Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8 PMID:18622397
- Cipollina C, et al. (2008) Saccharomyces cerevisiae SFP1: at the crossroads of central metabolism and ribosome biogenesis. Microbiology (Reading) 154(Pt 6):1686-1699 PMID:18524923
- Dudley AM, et al. (2005) A global view of pleiotropy and phenotypically derived gene function in yeast. Mol Syst Biol 1:2005.0001 PMID:16729036
- Lesage G, et al. (2004) Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin. Genetics 167(1):35-49 PMID:15166135
- Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 PMID:12140549