SET1 / YHR119W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

SET1/YHR119W is a non-essential gene; null mutants are viable and exhibit a range of phenotypic abnormalities that significantly impact cellular functions and overall fitness. These mutants display abnormal bud morphology and budding patterns, as well as irregular cell shape and cell wall morphology. Chromosome and plasmid maintenance are decreased, leading to potential genomic instability. The appearance and size of colonies are abnormal and reduced, respectively, indicating impaired growth. Competitive fitness is diminished, making these mutants less viable in competitive environments. The endomembrane system morphology is abnormal, which may affect intracellular transport and organization. Fermentative metabolism is increased, suggesting a shift in metabolic pathways. Flocculation is also increased, which could affect cell aggregation and sedimentation. These mutants show decreased resistance to gamma rays, indicating heightened sensitivity to DNA damage. The replicative lifespan is shortened, and silencing of certain genes is decreased, potentially affecting gene expression regulation. Sporulation efficiency is reduced, impacting reproductive success. The survival rate in the stationary phase is decreased, indicating lower resilience during nutrient scarcity. Telomere length is also reduced, which may affect chromosome stability and cellular aging.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources