APQ12 / YIL040W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant has a large cell size with abnormally elongated bud, and an anaphase delay; null mutant is heat and cold sensitive, slow growing at permissive temperature and has competitive fitness defects; null mutant is sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents, accumulating sterol precursors and monounsaturated fatty acids at reduced temperatures; null mutant is defective in the nuclear export of poly(A)+ mRNA, mislocalizes nuclear pore complex (NPC) cytoplasmic filament proteins and mRNA export factor, Dbp5p; null mutant has a vacuolar fragmentation deficiency, and nuclear morphology defects with abnormal nuclear envelope and NPC distribution; null mutant displays filamentous growth defects and is unable to undergo invasive growth; null mutant has decreased chronological lifespans, decreased acquired thermotolerance and does not accumulate trehalose after heat shock; null mutant is sensitive to metal treatment and antifungals

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources