HOP1 / YIL072W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

HOP1/YIL072W is non-essential for vegetative growth in S288C (hop1Δ is viable) but is critical for meiosis: deletion abolishes spore germination in SK1, and in S288C/XJ24-24a it reduces sporulation efficiency and meiotic recombination; the hypomorphic hop1-loop2 allele lowers double-strand break formation, and reduces spore viability. Loss or overexpression of HOP1 causes chromosome instability, with increased chromosome loss, colony sectoring, and elevated loss of heterozygosity. Fitness effects are condition-dependent: hop1Δ is haploinsufficient in FPM turbidostat growth, shows reduced competitive fitness in synthetic oak exudate, and a slight fitness increase on minimal medium; newly germinated spores grow more slowly, and a myo-inositol auxotrophy is reported. Starvation resistance and chronological lifespan are decreased.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources