Protein Help

SPO22 / YIL073C Protein

Protein abundance data, domains, shared domains with other proteins, protein sequence retrieval for various strains, sequence-based physico-chemical properties, protein modification sites, and external identifiers for the protein.


Aliases
ZIP4 4
Feature Type
ORF , Verified

AlphaFold Protein Structure

AlphaFold, developed by DeepMind, is an AI program that accurately predicts protein structures from amino acid sequences, enabling visualization of protein conformations. The predicted structures can be accessed through the Protein Data Bank (PDB) and AlphaFold Protein Structure Database.


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Model Confidence

Very high
Confident
Low
Very low

Experimental Data

Contains experimentally-derived protein half-life data obtained using stable isotope labeling by amino acids (SILAC) coupled with mass spectrometry. This section also contains protein abundance data for both untreated and treated cells obtained from over 20 studies. These data have been normalized and converted to a common unit of molecules per cell.


Protein Half Life

No half-life data available for SPO22.

Protein Abundance

No protein abundance data available for SPO22.

Domains and Classification - S288C

Collection of computationally identified domains and motifs, as determined by InterProScan analysis; includes protein coordinates for the domain, a domain Description, a Source and corresponding accession ID, and the number of S. cerevisiae genes that share the same domain.


Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene Protein Coordinates Accession ID Description Source No. of Genes with Domain

Domain Locations

Visual representation of the locations of the domains within the protein, as listed in the Domains and Classification table. Each row displays the domain(s) derived from a different Source, with domains color-coded according to this Source.

Scroll over a domain to view its exact coordinates and its Description.

Shared Domains

This diagram displays domains (colored squares) shared between the given protein (yellow circle) and other proteins (gray circles); the domains are color-coded according to their source, as displayed in the Domain Locations table, above.

Reset

Click on a gene or domain name to go to its specific page within SGD; drag any of the gene or domain objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram.

Alleles

Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.


spo22-Δ

View all SPO22 alleles in SGD search

Sequence

Protein sequence for the given gene in S288C and other strains, when available. Use the pull-down menu under "Strain" to select the sequence for a specific strain. The displayed sequence can be downloaded in FASTA format as a .txt file. Amino acids displayed in blue represent modification sites. More detailed evidence for these modification sites is presented in the Post-translational Modifications table, located just below the protein sequence.


1 MSDHNVNSTF RKTLVELCET ATWITSQVYA AKNLEKNDLI TVDNKISALY PIAEKYDRSF
61 RTTTVILDEE LILKLENAAS SLWNSLTIAM KAEKASDKYF NEVFCKCKIF ATKLLSIHEA
121 LFRTNTNLLR NFKCYISSFK SASEYRFDDL ITNTQQHSEK YLQIINENVE SFSNEEKTEF
181 KKLTFEFYLV NFQLYLSEND LDTANIYTAK VNITDNSKYM DADLLIELCR MIYNSTVMLK
241 EINNPETQLV DVNIISFLKD VEKYLELPVE NLKSHTDYSN LKYSVLIFMA NCLVEGHPQA
301 SELEQCDHYL SLLQNEYPNK VDPFILAINL TKRRNIVNPA ETIEEILMRM IMSVDVISNF
361 QAVIASINDL SKMNTKFSIV CLDYLLINKL NSKNDSKFLG KAICSRFLIT TQSKTMNDSE
421 IAESLENFST QMERIVSEPL TKHAISCIIT LLWNTGKKLE KMEKYVVSIR FYKLALKDII
481 SQNYSDRGKI QRALQVVYNK IEDYSNTVRV YQDMDEVDRQ SPLCQLLMLQ SFLADDKTEE
541 ALTCLQKIKS SEDEKSTDAL ILAVAECKRK TDLSVQGLLM IFDKLQSKSN SQTISSTSSS
601 QTLSILRYTL QMIVKVSEEE PLETFINYLP TVQKLLQKAV EFLKTVKLLN QLPPDVEKEA
661 IYQQSVAVNE IEWFASFSYN VAVKCLVDQS CESISEFPQY CIQFIDLIPV QDFTFPKMYH
721 FTYWRFKATI LQLIIAKEKA KQDQHQKDWD IYEKSEELVN SINVMKKSSE FKDGSSLEDR
781 NTLHECFLEA LTIHLESALM MPDQTRILDI LKKTELYQDS RVDALLIDIS SNMEDLPKGV
841 LIEILETVLK RNMGPEVKER ELCSWLRILL ENAINLNHEV ELRILDRVLK ILNINQSSLQ
901 DTDGVLQTEL ETIATYCWNI GVNYIIKDNK SNGIVWCKHS MGFANMVNEG LQEQLYSLWE
961 SLASSANIDI NSIAK*

* Blue amino acids indicate modification sites. More information below.

Post-translational Modifications - S288C

Modification sites for the protein in the selected strain, based on the presence of a residue in the specific strain, as inferred from experimental evidence.

3 entries for 3 sites

Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

SiteModificationModifierReference
K160sumoylated lysineBhagwat NR, et al. (2021) PMID: 33502312
S550phosphorylated residueLanz MC, et al. (2021) PMID: 33491328
K975sumoylated lysineBhagwat NR, et al. (2021) PMID: 33502312
Showing 1 to 3 of 3 entries

Sequence-Based Physico-chemical Properties - S288C

Calculated protein properties, including amino acid composition, length, coding region calculations, and atomic composition.

Amino Acid Composition

Sort table using the arrow to the right of a column header to sort by that column; download all properties as a .txt file using the "Download Properties" button.

Amino AcidFrequencyPercentage
A495.03
C202.05
D555.64
E818.31
F383.90
G131.33
H131.33
I828.41
K788.00
L11712.00
M252.56
N676.87
P191.95
Q454.62
R282.87
S868.82
T575.85
V565.74
W101.03
Y363.69

Physical Details

Length (a.a): 975
Molecular Weight (Da): 112405.0
Isoelectric Point (pl): 4.87
Formula: C5021H7969N1285O1539S45
Aliphatic Index: 95.55
Instability Index: 46.92

Coding Region Translation Calculations

Codon Bias: -0.06
Codon Adaptation Index: 0.12
Frequence of Optimal Codons: 0.41
Hydropathicity of Protein: -0.2
Aromaticity Score: 0.09

Extinction Coefficients at 280nm

ALL Cys residues appear as half cystines: 109890.0
NO Cys residues appear as half cystines: 108640.0

Atomic Composition

Sort table using the arrow to the right of a column header to sort by that column; download all properties as a .txt file using the "Download Properties" button.

Atom Frequency Percentage

Data not found or not available for  S288C

External Identifiers

List of external identifiers for the protein from various database sources.

14 entries for 7 sources


Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

External IDSource
orf19.6222CGD
556874GenBank/EMBL/DDBJ
Z37997GenBank/EMBL/DDBJ
CAA86097.1GenBank/EMBL/DDBJ
37362662GenBank/EMBL/DDBJ
73620996GenBank/EMBL/DDBJ
4375LoQAtE
DAA08477.1NCBI
854737NCBI
NM_001179423.1NCBI
Showing 1 to 10 of 14 entries

Resources


Homologs

AGD | BLASTP at NCBI | CGD | FungiDB | PhylomeDB | YGOB | YOGY

Protein Databases

AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB

Localization

CYCLoPs | dHITS | LoQAtE | YeastGFP | YeastRGB | YPL+

Post-translational Modifications

PhosphoGRID | PhosphoPep