Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
32 entries for 21 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| cell cycle progression in M phase: delayed | classical genetics | conditional Allele: sln1-ts4 | W303 | Temperature: elevated temperature, 37 °C Treatment: metaphase-block release Details: constitutive activation of Hog1p in metaphase-synchronized cells results in both delayed nuclear division and progression into a new G1 phase; suppressed by HOG1 deletion | Tognetti S, et al. (2020) PMID:32265285 | |
| cell cycle progression in S phase: delayed | classical genetics | conditional Allele: sln1-ts4 | Other | Temperature: elevated temperature, 37 °C Treatment: alpha-factor block release Treatment: hydroxyurea block release Treatment: osmotic stess, 0.4 M NaCl | Yaakov G, et al. (2009) PMID:19477922 | |
| chromosome segregation: abnormal | classical genetics | conditional Allele: sln1-ts4 | W303 | Temperature: elevated temperature, 37 °C Treatment: metaphase-block release Details: constitutive activation of Hog1p in metaphase-synchronized cells delays and impairs the segregation of rDNA and telomeric regions, both late segregating regions | Tognetti S, et al. (2020) PMID:32265285 | |
| chromosome/plasmid maintenance: decreased | large-scale survey | repressible | S288C | 10 ug/ml doxycycline | Details: Tet-regulated essential ORF strain collection (doxycycline represses expression)|; increased chromosome rearrangements and chromosome loss, as measured in an illegitimate mating assay | Cheng E, et al. (2012) PMID:22673806 |
| competitive fitness: decreased | competitive growth fitness profiling of essential genes using hypomorphic DAmP alleles | reduction of function | S288C | Media: minimal medium Details: Relative fitness score: 0.978 | Breslow DK, et al. (2008) PMID:18622397 | |
| haploinsufficient | heterozygous diploid, systematic mutation set | null Allele: sln1-Δ | S288C | Ohnuki S and Ohya Y (2018) PMID:29768403 | ||
| hyperosmotic stress resistance: decreased | classical genetics | activation Allele: sln1-(nrp2-3) P1196L | Other | 0.9 M sodium chloride | Media: rich medium, YPD | Fassler JS, et al. (1997) PMID:9148959 |
| inviable | systematic mutation set | null Allele: sln1-Δ | S288C | Giaever G, et al. (2002) PMID:12140549 | ||
| inviable | classical genetics | null Allele: sln1-Δ | Other | Media: rich medium, YPD | Ota IM and Varshavsky A (1993) PMID:8211183 | |
| metal resistance: decreased | systematic mutation set | overexpression | S288C | 20 mM manganese(II) chloride | Details: exacerbates toxicity | Chakrabortee S, et al. (2016) PMID:27693355 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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