CSE4 / YKL049C Homology


Standard Name
CSE4 1
Systematic Name
YKL049C
SGD ID
SGD:S000001532
Aliases
CSL2 14
Feature Type
ORF , Verified
Description
Centromeric histone H3-like protein; associates with promoters, accessible chromatin and RNAPII-bound regions; centromeric association promotes kinetochore assembly and Sgo1p association with CEN chromatin; Ipl1p-dependent phosphorylation destabilizes defective kinetochores promoting biorientation; phosphorylation by Cdc7p maintains Cse4p at kinetochores and promotes chromosome segregation; R37 methylation regulates kinetochore function and chromosome segregation; complements human homolog CENPA 1 2 3 4 5 6 7 8 9 10 11 12 13
Name Description
Chromosome SEgregation 1
Comparative Info

Homologs

Homology calls are sourced from the Alliance of Genome Resources. Many aspects of data integration presented at the Alliance require a common set of orthology relationships among genes for the organisms represented, including human. The Alliance provides the results of all methods that have been benchmarked by the Quest for Orthologs Consortium (QfO). The homolog inferences from the different methods have been integrated using the DRSC Integrative Ortholog Prediction Tool (DIOPT), which integrates a number of existing methods including those used by the Alliance: Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, and ZFIN.


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Species Gene ID Gene name Source

Functional Complementation

Information about cross-species functional complementation between yeast and other species, curated by SGD and the Princeton Protein Orthology Database (P-POD).

2 entries for 2 complements


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SpeciesGene IDStrain backgroundDirectionDetailsSourceReference
Homo sapiensHGNC:1851S288Cyeast complements otherCENP-A expression was ablated by RNAi.P-PODWieland G, et al. (2004)
PMID:15254229
Homo sapiensHGNC:27252S288Cother complements yeastHuman H2BFWT rescues the growth defect of an S. cerevisiae temperature sensitive allele of cse4 at elevated temperatures, although these two homologous genes are not orthologous.SGDYang F, et al. (2017)
PMID:28542158
Showing 1 to 2 of 2 entries

Fungal Homologs

Fungal Homology calls are sourced from AllianceMine, which compiles fungal homology calls from FungiDB, CGD, Panther, PomBase, TreeFam, HomoloGene, and SGD.


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Species Gene ID Gene name Description Source

External Identifiers

List of external identifiers for the protein from various database sources.

30 entries for 10 sources


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External IDSource
orf19.6163CGD
8048DIP
27808712GenBank/EMBL/DDBJ
AAB60309.1GenBank/EMBL/DDBJ
CAA81884.1GenBank/EMBL/DDBJ
Z28049GenBank/EMBL/DDBJ
429544115GenBank/EMBL/DDBJ
U20327GenBank/EMBL/DDBJ
X71621GenBank/EMBL/DDBJ
1169108GenBank/EMBL/DDBJ
Showing 1 to 10 of 30 entries

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