RAD27 / YKL113C Homology
- Standard Name
- RAD27 1
- Systematic Name
- YKL113C
- SGD ID
- SGD:S000001596
- Aliases
- ERC11 27 , RTH1 10 , FEN1 28
- Feature Type
- ORF , Verified
- Description
- 5' to 3' exonuclease, 5' flap endonuclease; required for Okazaki fragment processing and maturation, for long-patch base-excision repair and large loop repair (LLR), ribonucleotide excision repair; cleaves off RNA flap in a RNA:DNA hybrid intermediate during processing of DNA lagging strand; relocalizes to the cytosol in response to hypoxia; member of the S. pombe RAD2/FEN1 family 2 3 4 5 6 7
- Name Description
- RADiation sensitive 1
- Comparative Info
-
Homologs
Homology calls are sourced from the Alliance of Genome Resources. Many aspects of data integration presented at the Alliance require a common set of orthology relationships among genes for the organisms represented, including human. The Alliance provides the results of all methods that have been benchmarked by the Quest for Orthologs Consortium (QfO). The homolog inferences from the different methods have been integrated using the DRSC Integrative Ortholog Prediction Tool (DIOPT), which integrates a number of existing methods including those used by the Alliance: Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, and ZFIN.
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| HOMOLOG ID | Species | Gene ID | Gene name | Source |
|---|
Functional Complementation
Information about cross-species functional complementation between yeast and other species, curated by SGD and the Princeton Protein Orthology Database (P-POD).
6 entries for 6 complementsIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| Species | Gene ID | Strain background | Direction | Details | Source | Reference |
|---|---|---|---|---|---|---|
| Homo sapiens | HGNC:3511 | S288C | other complements yeast | This paper shows that a truncated 803aa peptide of hEXO1, like yeast Exo1p, is capable of suppressing the mutator phenotype of rad27 yeast. The Ensembl peptides listed here each have 846 aa. | P-POD | Tishkoff DX, et al. (1998) PMID:9823303 |
| Homo sapiens | HGNC:3650 | S288C | other complements yeast | P-POD | Guo Z, et al. (2008) PMID:18443037 | |
| Homo sapiens | HGNC:3650 | S288C | other complements yeast | P-POD | Frank G, et al. (1998) PMID:9830061 | |
| Homo sapiens | HGNC:3650 | S288C | other complements yeast | P-POD | Greene AL, et al. (1999) PMID:10545607 | |
| Homo sapiens | HGNC:3650 | S288C | other complements yeast | P-POD | Lopes J, et al. (2006) PMID:16914748 | |
| Homo sapiens | HGNC:3650 | S288C | other complements yeast | Human FEN1 complements the sensitivity of the S. cerevisiae rad27 null mutant, implicated in chromosomal instability (CIN), to methyl methanesulfonate, ethanol, cycloheximide and reverses the A-like faker phenotype. | SGD | Hamza A, et al. (2020) PMID:31937519 |
Fungal Homologs
Fungal Homology calls are sourced from AllianceMine, which compiles fungal homology calls from FungiDB, CGD, Panther, PomBase, TreeFam, HomoloGene, and SGD.
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| HOMOLOG ID | Species | Gene ID | Gene name | Description | Source |
|---|
External Identifiers
List of external identifiers for the protein from various database sources.
19 entries for 9 sourcesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
Resources
Homologs
AGD | AnalogYeast | BLASTP at NCBI | CGD | FungiDB | PhylomeDB | PomBase | YGOB | YOGY
Protein Databases
AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB
Localization
CYCLoPs | dHITS | LoQAtE | YeastGFP | YeastRC Public Images | YeastRGB | YPL+
Post-translational Modifications
CoSMoS.c. | PhosphoGRID | PhosphoPep
S288C only
BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species
BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi