SMC1 / YFL008W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Essential gene; heterozygous null is haploinsufficient, which results in chromosome instability; heterozygous null is sensitive to rapamycin; overexpression leads to increased forward mutation rate; reduced function alleles display greater rate of minichromosome nondisjunction, absent sporulation, decreased competitive fitness; conditional alleles show loss of sister chromatid cohesion, defects in rRNA processing, heat sensitivity, chromosome instability, decreased viability, sensitivity to Congo Red and Calcofluor White

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources