ECO1 / YFR027W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

ECO1/YFR027W is an essential gene; null mutants are inviable. Conditional mutants exhibit a range of phenotypic changes including arrested cell cycle progression through the G2/M phase transition, abnormal chromosome segregation and maintenance, decreased gamma ray and X-ray resistance, increased heat sensitivity, decreased mitotic recombination, abnormal nucleolar and spindle morphology, decreased oxidative stress resistance, decreased resistance to chemicals, altered RNA accumulation, decreased spore germination, decreased vegetative growth, and altered viability. Reduction of function mutants exhibit increased competitive fitness. Additionally, conditional mutants display increased colony sectoring and altered resistance to chemicals.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources