PTC1 / YDL006W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

PTC1/YDL006W is a non-essential gene; null mutants are viable but exhibit a range of phenotypic changes including decreased alkaline pH resistance, increased autophagy, auxotrophy, abnormal budding pattern, arrested cell cycle progression in the G1 phase, decreased competitive fitness, decreased cytokinesis, abnormal endoplasmic reticulum morphology, increased heat sensitivity, decreased ionic stress resistance, increased killer toxin resistance, abnormal lipid particle morphology, decreased metal resistance, abnormal mitochondrial distribution and morphology, decreased oxidative stress resistance, abnormal protein/peptide distribution and modification, decreased replicative lifespan, decreased resistance to enzymatic treatment, decreased respiratory growth rate, decreased small molecule transport, decreased sporulation, decreased telomere length, decreased toxin resistance, decreased utilization of carbon sources, abnormal vacuolar morphology, and decreased vegetative growth rate.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources