KCS1 / YDR017C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

KCS1/YDR017C is a non-essential gene; null mutants are viable but exhibit a variety of phenotypes including auxotrophy, increased cell size, abnormal chromosome/plasmid maintenance, increased cold sensitivity, increased heat sensitivity, decreased competitive fitness, abnormal endocytosis, decreased rate of fermentative growth, decreased growth rate in the exponential phase, decreased resistance to hyperosmotic stress, decreased innate thermotolerance, decreased invasive growth, decreased ionic stress resistance, decreased metal resistance, abnormal mitochondrial morphology, increased nutrient uptake, decreased pseudohyphal growth, absent or decreased sporulation, altered transposable element transposition, decreased utilization of carbon and nitrogen sources, abnormal vacuolar morphology, and decreased rate of vegetative growth. Conditional mutants also show increased heat sensitivity. Overexpression of KCS1 results in decreased vegetative growth rate and abnormal pseudohyphal growth.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources