Phenotype Help

AIM7 / YDR063W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene; null mutant has decreased competitive fitness in minimal medium, but increased fitness in rich medium containing 6% ethanol; null mutant has a reduced frequency of spontaneous mitochondrial genome loss; haploinsufficiency in the heterozygous diploid null mutant results in chromosomal instability; null mutant has increased innate thermotolerance in stationary phase; DL:LL dityrosine ratio is altered in spores of the null mutant

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

12 entries for 10 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
chromosome/plasmid maintenance: decreased
heterozygous diploid, systematic mutation setnull
Allele: aim7-Δ
S288CAssay: diploid bimater (BiM) assay
Details: haploinsufficiency results in chromosome instability (CIN); scored >= 2 standard deviations above the mean
Choy JS, et al. (2013) PMID:23825022
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: aim7-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.997
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: increased
systematic mutation setnull
Allele: aim7-Δ
S288CMedia: rich medium (YPD) w/6% ethanol, ETH
Qian W, et al. (2012) PMID:23103169
haploinsufficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: aim7-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: -0.0017
Pir P, et al. (2012) PMID:22244311
innate thermotolerance: increased
homozygous diploid, systematic mutation setnull
Allele: aim7-Δ
S288CPhase: stationary phase
Treatment: heat shock, 50 °C
Details: resistance scale of 1 (least) to 4 (most) resistant: 1
Jarolim S, et al. (2013) PMID:24142923
mitochondrial genome maintenance: abnormal
large-scale surveynull
Allele: aim7-Δ
S288CDetails: decreased frequency of spontaneous mitochondrial genome loss
Hess DC, et al. (2009) PMID:19300474
resistance to chemicals: decreased
systematic mutation setnull
Allele: aim7-Δ
S288C nickel(2+)Bishop AL, et al. (2007) PMID:17176259
resistance to chemicals: decreased
homozygous diploid, systematic mutation setnull
Allele: aim7-Δ
S288C chondramide derivativeHoepfner D, et al. (2014) PMID:24360837
resistance to chemicals: decreased
homozygous diploid, systematic mutation setnull
Allele: aim7-Δ
S288C0.01 mM glycolaldehydeDetails: > 10% sensitivity relative to the wild-type (p<0.05)
Jayakody LN, et al. (2011) PMID:20960220
sporulation: abnormal
homozygous diploid, systematic mutation set

Class 2a mutant

null
Allele: aim7-Δ
OtherDetails: Spores appear mature by visual inspection with light microscopy; DL:LL dityrosine ratio was altered relative to wild-type
Briza P, et al. (2002) PMID:11921089
Showing 1 to 10 of 12 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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