YAP6 / YDR259C Overview

Standard Name
YAP6 1
Systematic Name
HAL7 3
Feature Type
ORF , Verified
Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication 1 2 3 4 5
Name Description
Yeast homolog of AP-1 1
CIN5 5
Comparative Info
Sequence Details


The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.

YAP6 has a paralog, CIN5, that arose from the whole genome duplication
Protein Details


Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.

Length (a.a.)
Mol. Weight (Da)
Isoelectric Point
Median Abundance (molecules/cell)
682 +/- 668


Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.

View all YAP6 alleles in SGD search

Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.

Sequence-specific DNA-binding transcription factor that recruits the Cyc1/Tup1 transcriptional repressor complex to RNA polymerase II promoters to downregulate transcription

View computational annotations

Cellular Component

Manually Curated
Phenotype Details


Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.

Non-essential gene; overexpression impairs growth, increases filamentous growth, and decreases sensitivity to DNA-damaging agents; haploid null mutants show decreased competitive fitness and increased respiratory fitness; heterozygous diploid null are haploinsufficient and sensitive to DNA synthesis inhibitor methotrexate
Interaction Details


Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.

The yap6 null mutant is viable; the null mutant of paralog cin5 is viable; the yap6 cin5 double mutant has not been annotated for phenotype.

91 total interactions for 88 unique genes

Physical Interactions

  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 2
  • Biochemical Activity: 7
  • Two-hybrid: 40

Genetic Interactions

  • Dosage Growth Defect: 1
  • Dosage Lethality: 3
  • Dosage Rescue: 1
  • Negative Genetic: 30
  • Positive Genetic: 3
  • Synthetic Growth Defect: 1
Regulation Details


The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.

YAP6 encodes an AP-1 type transcription factor which contains a basic leucine zipper domain (bZIP), and binds to a consensus cis-acting Yap recognition element (YRE; 5'-TTAC/GTAA-3'). Yap6p is involved in the regulation of the osmotic stress response, and binds the promoters of dozens of genes, including those involved in the transport and catabolism of sugars and carbohydrates, and also those of ribosomal protein genes. In addition, Yap6p binds the promoters of over 40 different transcription factors, including its own. Yap6p is constitutively nuclear, and is induced upon exposure to various stress conditions, including osmotic and oxidative stress, and temperature shift. The YAP6 promotor is particularly rich in a variety of stress-associated cis-elements, including a YRE, a stress response elements (STRE), and three heat shock elements (HSE), enabling induction by multiple signalling pathways.
Expression Details


Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.

Literature Details


All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.