Phenotype Help

SWR1 / YDR334W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene; null mutant is temperature sensitive, has reduced competitive fitness in various growth media and decreased resistance to zinc-limited growth; null mutant has an increase in chronological lifespan and increased innate thermotolerance while in stationary phase; null has decreased UV resistance; null mutant displays increased sensitivity to transcriptional elongation and microtubule inhibitors

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

79 entries for 28 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
chemical compound accumulation: abnormal
systematic mutation setnull
Allele: swr1-Δ
S288C alpha-amino acidDetails: Significantly altered free amino acid profile (X^2- test p < 0.01)
Mülleder M, et al. (2016) PMID:27693354
chemical compound accumulation: decreased
homozygous diploidnull
Allele: swr1-Δ
S288C0.1 mM potassium tellurite, tellurium atomOttosson LG, et al. (2010) PMID:20675578
chromosome/plasmid maintenance: decreased
classical genetics null
Allele: swr1-Δ
S288CDetails: increase in chromosome instability (CIN) relative to wt using a single-cell quantitative chromosome transmission fidelity (qCTF) assay that detects the loss of an ectopic chromosomal fragment of chrIII
Gordon MR, et al. (2023) PMID:36350688
chronological lifespan: decreased
systematic mutation set null
Allele: swr1-Δ
S288CCampos SE, et al. (2018) PMID:29575540
chronological lifespan: increased
classical geneticsnull
Allele: swr1-Δ
S288C glutamineMedia: nitrogen-rich conditions
Details: increased CLS relative to wt in nitrogen-rich medium
Garay E, et al. (2014) PMID:24586198
chronological lifespan: increased
competitive growth

competitive survival of stationary phase co-cultures

null
Allele: swr1-Δ
S288CGaray E, et al. (2014) PMID:24586198
chronological lifespan: increased
classical geneticsnull
Allele: swr1-Δ
S288C gamma-aminobutyric acidMedia: nitrogen starvation
Details: small increase in CLS relative to wt during dietary restriction
Garay E, et al. (2014) PMID:24586198
colony sectoring: increased
homozygous diploid null
Allele: swr1-Δ
OtherDetails: chromosome missegration, leading to a 7.2-fold increase in chromosome loss, using colony half-sectoring analysis; indicative of chromosome instability (CIN)
Krogan NJ, et al. (2004) PMID:15353583
competitive fitness: decreased
homozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: swr1-Δ
S288CMedia: YPD
Details: Relative fitness score: 0.931
Deutschbauer AM, et al. (2005) PMID:15716499
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: swr1-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.883
Breslow DK, et al. (2008) PMID:18622397
Showing 1 to 10 of 79 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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